Tendon Biomechanics and Mechanobiology—A Minireview of Basic Concepts and Recent Advancements

TL;DR: The present meta-analysis provides elaborate statistical evidence that tendons are highly responsive to diverse loading regimens and strongly suggests that loading magnitude in particular plays a key role for tendon adaptation in contrast to muscle contraction type.

TL;DR: The results strongly support the new characteristics of PRF as a bioscaffold and reservoir of growth factors for tissue regeneration and regulate mineralization differentiation of hABMSC.

TL;DR: A design strategy for constructing high performance On-Off MRL materials by introducing nitrophenyl groups to molecules with aggregation-induced emission characteristic, which effectively opens the nonradiative ISC channel to impart the high sensitivity and contrast On–Off behavior.

TL;DR: The main mechanical cues that stem cells experience in their native microenvironment are summarized and recent advances in the design of hydrogel materials with spatiotemporally tunable mechanical properties for engineering 3D the spatiotsemporal mechanical microenvironment of stem cells are highlighted.

TL;DR: Full understanding of these physiological processes will provide the physiological basis for understanding of tissue overloading and injury seen in both tendons and muscle with repetitive work and leisure time physical activity.

TL;DR: Findings clearly indicate that, at least in an urban population, degenerative changes are common in the tendons of people who are older than thirty-five years and that these changes are associated with spontaneous rupture.

TL;DR: It is shown that human and mouse tendons harbor a unique cell population, termed tendon stem/progenitor cells (TSPCs), that has universal stem cell characteristics such as clonogenicity, multipotency and self-renewal capacity and could regenerate tendon-like tissues after extended expansion in vitro and transplantation in vivo.

TL;DR: An increased alpha-SMA expression is sufficient to enhance fibroblast contractile activity, with the use of silicone substrates of different stiffness degrees.