Journal Article10.1016/J.CHROMA.2016.01.023
Targeting tryptophan and tyrosine metabolism by liquid chromatography tandem mass spectrometry.
Josep Marcos,Nuria Renau,Olga Valverde,Gemma Aznar-Laín,Irene Gracia-Rubio,Marta Gonzalez-Sepulveda,Luis A. Pérez-Jurado,Rosa Ventura,Jordi Segura,Oscar J. Pozo +9 more
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TL;DR: A rapid, accurate and sensitive method based on liquid chromatography-tandem mass spectrometry for the targeted analysis of the metabolism of Trp and Tyr has been developed and validated and the applicability was confirmed by analyzing urine samples collected from 13 healthy volunteers and comparing the results with previously established normal ranges.
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About: This article is published in Journal of Chromatography A. The article was published on 19 Feb 2016. The article focuses on the topics: Liquid chromatography–mass spectrometry & Tandem mass spectrometry.
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Citations
Tryptophan in health and disease.
TL;DR: The role of TRP metabolism in health and disease is presented and Disorders involving the central nervous system, malignancy, inflammatory bowel and cardiovascular disease are discussed.
236
Recent trends in analytical methods for the determination of amino acids in biological samples.
TL;DR: This review describes the analytical methods reported in 2012–2016 that utilized liquid chromatography and capillary electrophoresis coupled with ultraviolet, fluorescence, mass spectrometry, and electrochemical detection and the relationship between amino acid concentrations and several diseases.
104
Urinary intermediates of tryptophan as indicators of the gut microbial metabolism
Tereza Pavlová,Veronika Vidova,Julie Bienertova-Vasku,Petr Janku,Martina Almáši,Jana Klánová,Zdenek Spacil +6 more
TL;DR: This study represents the first attempt to explore previously unreported microbial metabolites in urine by UHPLC-SRM and novel methodology for simultaneous determination of microbiota-modulated component of Trp metabolism.
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The Role of Tryptophan Metabolites in Neuropsychiatric Disorders
TL;DR: The efficiency of various biomarkers such as inflammatory, protein, electrophysiological, genetic, and proteomic biomarkers in the diagnosis/treatment of neuropsychiatric disorders was discussed to understand the biomarker application in the detection/ treatment of various diseases.
Quantification of endogenous neurotransmitters and related compounds by liquid chromatography coupled to tandem mass spectrometry
Eulàlia Olesti,Jose Rodríguez-Morató,Alex Gomez-Gomez,Johannes G. Ramaekers,Rafael de la Torre,Oscar J. Pozo +5 more
TL;DR: A straightforward liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of 16 endogenous small polar compounds in rat plasma and brain homogenates and obtained a neuro-metabolic fingerprint of each drug that reflected their pharmacological profile.
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References
Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain
TL;DR: Intracerebral injection of the neuroexcitatory tryptophan metabolite, quinolinic acid, has behavioral, neurochemical and neuropathological consequences reminiscent of those of exogenous excitotoxins, such as kainic and ibotenic acids.
1.3K
Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino Acids
TL;DR: The main determinant of brain tryPTophan and serotonin concentrations does not appear to be plasma tryptophan alone, but the ratio of this amino acid to other plasma neutral amino acids that compete with it for uptake into the brain.
1.1K
•Journal Article
Precursor control of neurotransmitter synthesis.
TL;DR: This relationship allows precursor administration to produce selective physiologic effects by enhancing neurotransmitter release from some but not all of the neurons potentially capable of utilizing the precursor for this purpose, and allows the investigator to predict when administering the precursor might be useful for amplifying a physiologic process, or for treating a pathologic state.
701
Increased cortical kynurenate content in schizophrenia.
Robert Schwarcz,Arash Rassoulpour,Hui Qiu Wu,Deborah R. Medoff,Carol A. Tamminga,Rosalinda C. Roberts +5 more
TL;DR: In rats, chronic treatment with haloperidol did not cause an increase in kynurenate levels in the frontal cortex, indicating that the elevation observed in schizophrenia is not due to antipsychotic medication.
582
Neutral amino acids in the brain: changes in response to food ingestion.
TL;DR: The diet‐induced changes in the brain level of each of the amino acids also correlate surprisingly well with the calculated rate of brain influx for each amino acid.
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