Targeted delivery of doxorubicin using stealth liposomes modified with transferrin.

TL;DR: Liposomes, an early version of LNPs, are a versatile nanomedicine delivery platform for treatment of a variety of diseases, such as antitumor and nucleic acid therapeutics and vaccine delivery systems as mentioned in this paper.

TL;DR: Challenges Eun-Kyung Lim,†,‡,§ Taekhoon Kim, Soonmyung Paik, Seungjoo Haam, Yong-Min Huh,*,† and Kwangyeol Lee

TL;DR: This review will discuss the barrier issue from a biological and pathological perspective to provide a better insight to the challenges and opportunities associated with the BBB.

TL;DR: The present article discusses the strategies used to target the TfR for the delivery of therapeutic agents into cancer cells and provides a summary of the vast types of anti-cancer drugs that have been delivered intocancer cells employing a variety of receptor binding molecules.

TL;DR: The potential role of DNA synthesis inhibition, free radical formation and lipid peroxidation, DNA binding and alkylation, DNA cross-linking, interference with DNA strand separation and helicase activity, direct membrane effects, and the initiation of DNA damage via the inhibition of topoisomerase II in the interaction of these drugs with the tumor cell are addressed.

TL;DR: The OX26 monoclonal antibody against the rat transferrin receptor offers great promise in the delivery of therapeutic agents across the blood-brain barrier to the brain and serves as a potential alternative to viral vector for gene therapy.

TL;DR: The advantage of this method versus one-step zero-length crosslinking is that only one component of the complex is exposed to the crosslinker, which eliminates complications arising from the formation of crosslinks among several proteins of a multicomponent complex.