TAM-targeted reeducation for enhanced cancer immunotherapy: Mechanism and recent progress
Xinyuan Shen,Shengcheng Zhou,Yidong Yang,Tu Hong,Ze Xiang,Jing Zhao,Chaojie Zhu,Ling-Hui Zeng,Ling-nan Zhang +8 more
TL;DR: In this paper , the potential TAM re-education targets for potentiating cancer immunotherapy and the underlying mechanisms are summarized in this review, and the most recent advances in utilizing nanomedicine for TAM immunomodulation for augmented cancer Immunotherapy are introduced.
read more
Abstract: Tumor-associated macrophage (TAM) as an important component of tumor microenvironment (TME) are closely related with the occurrence, development, and metastasis of malignant tumors. TAMs are generally identified as two distinct functional populations in TME, i.e., inflammatory/anti-tumorigenic (M1) and regenerative/pro-tumorigenic (M2) phenotype. Evidence suggests that occupation of the TME by M2-TAMs is closely related to the inactivation of anti-tumor immune cells such as T cells in TME. Recently, efforts have been made to reeducate TAMs from M2- to M1- phenotype to enhance cancer immunotherapy, and great progress has been made in realizing efficient modulation of TAMs using nanomedicines. To help readers better understand this emerging field, the potential TAM reeducation targets for potentiating cancer immunotherapy and the underlying mechanisms are summarized in this review. Moreover, the most recent advances in utilizing nanomedicine for the TAM immunomodulation for augmented cancer immunotherapy are introduced. Finally, we conclude with our perspectives on the future development in this field.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The role of metabolic reprogramming of tumor-associated macrophages in shaping the immunosuppressive tumor microenvironment.
TL;DR: The metabolic changes in TAMs are significantly associated with polarization towards a protumour or antitumour phenotype as mentioned in this paper , and the metabolites generated via TAM metabolic reprogramming in turn promote tumor progression and immune tolerance.
21
Macrophage polarization in the tumor microenvironment: Emerging roles and therapeutic potentials
Wenru Zhang,Baojun Gu,Baojun Gu,Baojun Gu,Baojun Gu,Baojun Gu +5 more
TL;DR: Macrophage polarization in the TME is a complex process that influences tumor initiation and progression. TAMs are polarized into M1 and M2 subtypes, and their interplay with the TME can impact tumor progression. Modulating macrophage polarization is a promising cancer therapy strategy.
16
Targeted delivery of pexidartinib to tumor-associated macrophages via legumain-sensitive dual-coating nanoparticles for cancer immunotherapy.
Desheng Liang,Weiliang You,Fang-Fang Zhu,Jia-Hui Wang,Feng Guo,Jian-Jun Xu,Xin-Liang Liu,Haijun Zhong +7 more
TL;DR: In this article , a legumain-sensitive dual-coating nanosystem (s-Tpep-NPs) was employed to deliver CSF-1R inhibitor pexidartinib (PLX3397) for targeting TAM therapy.
8
Biological function, regulatory mechanism, and clinical application of mannose in cancer.
Haoyi Jin,Xi Liu,Hong-Xu Liu +2 more
- 01 Aug 2023
TL;DR: The progress made in understanding the regulatory roles of mannose in cancer progression, the mechanisms underlying its anticancer effects, and its current application in cancer diagnosis and treatment are discussed.
8
Association between Intratumoral CD8+ T Cells with FoxP3+ and CD163+ Cells: A Potential Immune Intrinsic Negative Feedback Mechanism for Acquired Immune Resistance
Sotirios P Fortis,Michail Sofopoulos,Maria Goulielmaki,Niki Arnogiannaki,Alexandros Ardavanis,Sonia A. Perez,Angelos D. Gritzapis,Constantin N. Baxevanis +7 more
TL;DR: In this paper , the authors demonstrate that high frequencies of CD163+ and FoxP3+ cells in the tumors of patients with breast cancer coexist with CD8+ cells only when the latter are also in dense frequencies.
References
Exploring the full spectrum of macrophage activation.
TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
4.6K
Tumor-associated macrophages: from mechanisms to therapy.
TL;DR: Therapeutic success in targeting these protumoral roles in preclinical models and in early clinical trials suggests that macrophages are attractive targets as part of combination therapy in cancer treatment.
3.7K
Tumour-associated macrophages as treatment targets in oncology
Alberto Mantovani,Federica Marchesi,Federica Marchesi,Alberto Malesci,Alberto Malesci,Luigi Laghi,Paola Allavena +6 more
TL;DR: It is surmised that TAMs can provide tools to tailor the use of cytoreductive therapies and immunotherapy in a personalized medicine approach, and that TAM-focused therapeutic strategies have the potential to complement and synergize with both chemotherapy and immunotherapies.
The microenvironment of the tumour-host interface
Lance A. Liotta,Elise C. Kohn +1 more
TL;DR: A new class of cancer therapies that targets this pathological communication interface between tumour cells and host cells is currently under development.
2.4K