Talin at a glance.
TL;DR: These large multiprotein complexes assemble around the integrin family of cell adhesion molecules (transmembrane αβ heterodimers) that are typically linked with each other.
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Abstract: Cell migration, growth and differentiation all require the assembly and disassembly of cellular junctions with the extracellular matrix (ECM). These large multiprotein complexes assemble around the integrin family of cell adhesion molecules (transmembrane αβ heterodimers) that are typically linked
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Citations
The final steps of integrin activation: the end game
TL;DR: Recent progress provides insight into the structure of integrin transmembrane domains, and reveals how the final steps of Integrin activation are mediated by integrin-binding proteins such as talins and kindlins.
Integrin signalling at a glance
TL;DR: Integrins are a major family of cell-surface-adhesion receptors that are expressed in all metazoans and the specific binding of these receptors is unknown.
Genetic and cell biological analysis of integrin outside-in signaling.
TL;DR: This review discusses recent work that has tremendously broadened the understanding of the complexity of integrin-mediated signaling.
The Tail of Integrins, Talin, and Kindlins
TL;DR: This review focuses on the mechanisms whereby two key proteins, talin and the kindlins, regulate integrin activation by binding the tails of integrin-β subunits.
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Integrins and Extracellular Matrix in Mechanotransduction
TL;DR: Current knowledge about regulation of cell function by mechanical forces acting through integrin-mediated adhesions is summarized and models for mechanotransduction and sensing of environmental forces are discussed.
References
Functional atlas of the integrin adhesome
TL;DR: Examination of the adhesome network motifs reveals a relatively small number of key motifs, dominated by three-component complexes in which a scaffolding molecule recruits both a signalling molecule and its downstream target.
Vinculin controls focal adhesion formation by direct interactions with talin and actin
Jonathan D. Humphries,Pengbo Wang,Charles H. Streuli,Benny Geiger,Martin J. Humphries,Christoph Ballestrem +5 more
TL;DR: The vinculin head regulates integrin dynamics and clustering and the tail regulates the link to the mechanotransduction force machinery, which is responsible for the functional link of FAs to the actin cytoskeleton.
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Calpain-mediated proteolysis of talin regulates adhesion dynamics
Santos J. Franco,Mary A. Rodgers,Benjamin J. Perrin,Jaewon Han,David A. Bennin,David R. Critchley,Anna Huttenlocher +6 more
TL;DR: It is demonstrated that disassembly of other adhesion components, including paxillin, vinculin and zyxin, is also dependent on the ability of calpain to cleave talin, suggesting a general role for talin proteolysis in regulating adhesion turnover.
591
The structure and regulation of vinculin.
TL;DR: The finding that vinculin modulates the signalling pathways involved in apoptosis suggests that additional roles for vINCulin remain to be discovered.
507
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin
TL;DR: It is suggested that talin1 initially forms a molecular slip bond between closely packed fibronectin–integrin complexes and the actin cytoskeleton, which can apply a low level of force to fibronECTin until many bonds form or a signal is received to activate a force response.
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