Book Chapter10.1007/978-94-007-6612-9_1
Systems and Network Biology to Investigate Epigenetic De-regulatory Mechanisms of MicroRNAs in Pancreatic Cancer
Irfana Muqbil,Fazlul H. Sarkar,Ramzi M. Mohammad,Ramzi M. Mohammad,Asfar S. Azmi +4 more
- 01 Feb 2013
- pp 1-12
1
TL;DR: In this chapter, the aberrant epigenetic grooming of miRNAs especially in PC and computational strategies especially systems and network biology to target them are discussed.
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Abstract: Pancreatic cancer (PC) is highly resistant to conventional therapeutics, and it is a complex disease which is partly characterized by genetic and epigenetic de-regulation of many signaling pathways Among the numerous de-regulated mechanisms aberrant expression of small non-coding MicroRNAs (miRNAs) are very important Intense research in this area has lead to the identification and characterization of critically de-regulated miRNAs which raises our hope that targeting them may lead to clinically beneficial outcome of patients diagnosed with PC Emerging evidence suggests that miRNAs are under a highly coordinated epigenetic regulation, which could be exploited for the development of novel therapeutics For the success of miRNA based therapeutic regimens, a holistic approach may be required that takes into account the emerging epigenetic regulatory mechanisms In this chapter, the aberrant epigenetic grooming of miRNAs especially in PC and computational strategies especially systems and network biology to target them are discussed
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Citations
Genome-wide dissection of microRNA functions and cotargeting networks using gene-set signatures
John S. Tsang,John S. Tsang,Margaret S. Ebert,Alexander van Oudenaarden +3 more
- 01 Apr 2010
TL;DR: This work predicts human microRNA functions by using a new method that systematically assesses the statistical enrichment of several microRNA-targeting signatures in annotated gene sets such as signaling networks and protein complexes, and provides the first genome-wide evidence of pervasive cotargeting.
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