Patent
Synthesis method of 2,8-diaryl(amino) Troger's base derivatives
TL;DR: In this paper, a synthesis method of 2,8-diaryl(amino) Troger's base derivatives was revealed, which consists of 2(8)-triarylpyridyl (tripyridym), 2.8-triary ln-tripyrithm and 2-8-drilithm Troger base derivatives.
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Abstract: The invention discloses a synthesis method of 2,8-diaryl(amino) Troger's base derivatives, belonging to the synthesis method of the Troger's base derivatives. The 2,8-diaryl(amino) Troger's base derivatives comprise 2(8)-triarylpyridyl (tripyridyl) Troger's base (TB) derivative, 2,8-diaryl Troger's base (TB) derivative and 2-aryl-8-amino Troger's base (TB) derivative; the synthesis method adopts Suzuki reaction to respectively introduce triarylpyridyl, tripyridyl, phenyl, phenanthryl or anthryl fragment into the TB skeleton, and Ullmann reaction to introduce carbazole, diphenylamine or phenothiazine into the TB skeleton, to obtain the new 2,8-diaryl(amino) Troger's base (TB) derivatives. Four products with excellent human liver cancer HepG2 cell activity resistance are selected from all products with human liver cancer HepG2 cell activity resistance. The method introduces phenothiazine, carbazole and other fragments with physiological activities into the TB skeleton, to design and synthesize 2,8-diaryl(amino) Troger's base derivatives for the first time, so as to screen compounds with liver cancer activity resistance through the combination of both.
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References
Synthesis, resolution, and absolute configuration of difunctionalized Tröger's base derivatives.
TL;DR: Two racemic derivatives of Tröger's base were synthesized and successfully resolved by HPLC on a chiral stationary Whelk-01 phase on a semipreparative scale, thereby giving rise to both enantiomers in a pure form.
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Amorphous host materials based on Tröger's base scaffold for application in phosphorescent organic light-emitting diodes
TL;DR: With a limited experimentation of the devices, it is shown that the TBs doped with a green phosphor, namely, Ir(ppy)3, permit impressive external efficiencies on the order of ca.
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Organic amorphous hole-transporting materials based on Tröger's Base: alternatives to NPB
TL;DR: In this paper, the authors exploit the Troger's Base (TB) scaffold to create two amorphous hole-transporting materials (HTMs), i.e., TB1 and TB2, with high Tgs (152-156 °C) as alternatives to the popular NPB (Tg ∼ 95 °C).
Discovery of Tröger's base analogues as selective inhibitors against human breast cancer cell line: design, synthesis and cytotoxic evaluation.
TL;DR: Of the 30 compounds synthesized and evaluated, 7 compounds were found to possess cytotoxicity that is equivalent or better than standard drug doxorubicin against MDAMB-231 cell line while only one compound was found to be active against SK-N-SH cell line.
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One‐Step Synthesis of Tröger's Base Hybrids Containing at Least One Halogen Atom
TL;DR: One-step synthesis of a series of hybrid dibenzo Troger's base analogues bearing at least one halogen atom is described in this article, which involves a reaction between two different anilines and affords hybrid compounds in yields as high as 46% together with the symmetric Troger base products.
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