Journal Article10.17344/acsi.2023.8460
Synthesis and Cholinesterase Inhibitory Activity of Selected Indole-Based Compounds.
Uroš Grošelj,Marija Gršič,A. Meden,Damijan Knez,Marko Jukič,Jurij Svete,Stanislav Gobec +6 more
TL;DR: The synthesis and cholinesterase inhibitory activity of indole-based compounds are described. These compounds exhibit selective submicromolar inhibition of hBChE.
read more
Abstract: Synthesis and anticholinesterase activity of 18 previously unpublished indole- and tryptophan-derived compounds are disclosed. These sp3-rich compounds containing an indole structural unit exhibit selective submicromolar inhibition of human butyrylcholinesterase (hBChE). The structures of the newly synthesized compounds were confirmed by 1H and 13C NMR, IR spectroscopy, and high-resolution mass spectrometry.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
References
Indole alkaloid marine natural products: an established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases.
Waseem Gul,Mark T. Hamann +1 more
TL;DR: Specific biological activities of indole alkaloids presented here include: cytotoxicity, antiviral, antiparasitic, anti-inflammatory, serotonin antagonism, Ca-releasing, calmodulin antagonism and other pharmacological activities.
428
Indole: A privileged scaffold for the design of anti-cancer agents.
TL;DR: This review aimed to provide a clear knowledge on the recent development of indoles as anti-cancer agents, such as myeloid cell leukemia-1 (Mcl-1) inhibitors, proviral insertion site in moloney murine leukemia virus (Pim), and made an insight into the corresponding structure-activity relationships (SARs).
374
Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease.
TL;DR: An imaging agent is designed that can detect, through autoradiography, BChE-associated Aβ plaques in the cerebral cortex of AD brains, but does not visualize Aβ Plaques in brains of cognitively normal individuals, suggesting diminished B ChE activity could prove beneficial as a curative approach to AD.
164
A brief review of the biological potential of indole derivatives
Sunil Kumar,Ritika +1 more
TL;DR: From the literature, it is revealed that indole derivatives have diverse biological activities and also have an immeasurable potential to be explored for newer therapeutic possibilities.
152
Heterocyclic scaffolds as promising anticancer agents against tumours of the central nervous system: Exploring the scope of indole and carbazole derivatives.
Chris Sherer,Timothy J. Snape +1 more
TL;DR: This review highlights compounds in development for the treatment of tumours of the central nervous system which are structurally based on the indole, carbazole and indolocarbazole scaffolds, under the expectation that it will highlight new avenues for research for the development of new compounds to treat these devastating neoplasms.
144