Synthesis and biological evaluation of a cross-linked hyaluronan-mitomycin C hydrogel.

TL;DR: Although both fabrication and evaluation of structure–property relationships remain challenges, materials comprised of conducting polymers and hydrogels are promising for the next generation of bioactive electrode coatings.

TL;DR: Although, so far, there are no HA-drug conjugates on the market, several derivatives are presently under clinical investigation, and the promising results encourage further investigations and the exploitation of this versatile polysaccharide.

TL;DR: Hydrogels in which maleimide- functionalized low molecular weight heparin is crosslinked with various thiol-functionalized poly(ethylene glycol) (PEG) multi-arm star polymers are described, indicating the potential use of these Michael-type addition products for reduction-mediated release and/or degradation, with increased blood stability and prolonged drug delivery timescales compared to disulfide moieties.

TL;DR: The key biological functions of HA in the body in terms of its structure, physical properties, biodistribution and interaction with HA receptors are described and unique advantages that allow HA to be applied in various biomedical fields are described.

TL;DR: In this paper, a rapid, simultaneous double-staining procedure using fluorescein diacetate (FDA) and propidium iodide (PI) is described for use in the determination of cell viability in cell suspension.

TL;DR: This review on the properties of the new materials reports some of their biocompatibility and characterization aspects based on findings from studies conducted on the ethyl and benzyl hyaluronan esters, and is intended to arouse interest in the potential of other, as yet unexplored derivatives.

TL;DR: Intermittent dosage schedules are predicted to be better on the basis of pharmacokinetic and cytopathologic studies, and Tumors resistant to other alkylating agents are frequently sensitive to Mitomycin C.