Synform issue 2016/8
About: This article is published in Synlett. The article was published on 19 Jul 2016. and is currently open access.
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Citations
C-H Functionalisation for Hydrogen Isotope Exchange.
TL;DR: This Review describes recent advances in synthetic C-H functionalisation for hydrogen isotope exchange in the physical and life sciences.
Iridium-Catalyzed Formyl-Selective Deuteration of Aldehydes
TL;DR: This work reports the first direct catalytic method for formyl-selective deuterium labeling of aromatic aldehydes under mild conditions, using an iridium-based catalyst designed to favor formyl over aromatic C-H activation.
Hydrogen Isotope Exchange with Iridium(I) Complexes Supported by Phosphine-Imidazolin-2-imine P,N Ligands
Kristof Jess,Volker Derdau,Remo Weck,Jens Atzrodt,Matthias Freytag,Peter G. Jones,Matthias Tamm +6 more
TL;DR: Phenylene-bridged hybrid phosphine-imidazolin-2-imine RP,NR′ ligands (R=Ph, Cy, i-Pr, t-Bu; R′=Me, I-Pr) were prepared from 1,2-dibromobenzene by palladium-catalyzed C-N coupling with 1,3,4,5-tetramethylimidazoline-2,imine or 1, 3-diisopropyl-4, 5-dimethyliminamide-2
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Hydrogen-Isotope Exchange (HIE) Reactions of Secondary and Tertiary Sulfonamides and Sulfonylureas with Iridium(I) Catalysts
TL;DR: In this paper, the optimized hydrogen-isotope exchange (HIE) conditions for the selective aromatic deuteriation of various sulfonylureas and tertiary sulfonamides were reported.
37
Burgess iridium(I)-catalyst for selective hydrogen isotope exchange.
TL;DR: The broad applicability in hydrogen isotope exchange reactions makes the Burgess catalyst a possible alternative compared to other commercially available iridium(I)-catalysts.
36
References
CHAPTER 5:Ancillary Ligand Design in the Development of Palladium Catalysts for Challenging Selective Monoarylation Reactions
TL;DR: This chapter documents how the challenge of achieving monoarylation selectivity in palladium-catalyzed Buchwald–Hartwig amination and ketone α-arylation chemistry has been addressed in recent years through the design and/or implementation of sterically demanding phosphine ancillary ligands.
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