Journal Article10.1016/J.JINF.2013.09.001
Susceptibility of gram-negative aerobic bacilli from intra-abdominal pathogens to antimicrobial agents collected in the United States during 2011
Stephen P. Hawser,Robert E. Badal,Samuel K. Bouchillon,Daryl J. Hoban,Meredith Hackel,Douglas J. Biedenbach,Debra A. Goff +6 more
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TL;DR: Extended-spectrum beta-lactamase ESBL (ESBL) isolates determined using the Clinical and Laboratory Standards Institute's recommended phenotypic test showed susceptibility to ertapenem, with the carbapenems being the most active in vitro, including against ESBL-positive isolates of E. coli.
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About: This article is published in Journal of Infection. The article was published on 01 Jan 2014. The article focuses on the topics: Ertapenem & Broth microdilution.
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Citations
Carbapenem resistance, inappropriate empiric treatment and outcomes among patients hospitalized with Enterobacteriaceae urinary tract infection, pneumonia and sepsis.
TL;DR: In this large US database, the prevalence of CRE among patients with Enterobacteriaceae UTI, pneumonia or sepsis was comparable to other national estimates, and infection with CRE was associated with a four-fold increased risk of receiving IET, which in turn increased mortality, LOS and costs.
Multicenter, Double-Blind, Randomized, Phase II Trial To Assess the Safety and Efficacy of Ceftolozane-Tazobactam plus Metronidazole Compared with Meropenem in Adult Patients with Complicated Intra-Abdominal Infections
Christopher Lucasti,Ellie Hershberger,Benjamin Miller,Sara Yankelev,Judith N. Steenbergen,Ian Friedland,Joseph S. Solomkin +6 more
TL;DR: TOL-TAZ in combination with metronidazole was well tolerated and resulted in clinical and microbiological success rates supportive of further clinical development in patients with cIAIs that required surgical intervention.
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Antimicrobial susceptibilities of Proteus mirabilis : a longitudinal nationwide study from the Taiwan surveillance of antimicrobial resistance (TSAR) program
Jann-Tay Wang,Jann-Tay Wang,Pei-Chen Chen,Shan-Chwen Chang,Yih-Ru Shiau,Hui-Ying Wang,Jui-Fen Lai,I-Wen Huang,Mei-Chen Tan,Tsai-Ling Lauderdale +9 more
TL;DR: A significant decrease in susceptibility to 3rd-generation cephalosporins and ciprofloxacin occurred in Proteus mirabilis from Taiwan in the past decade and continuous surveillance on antimicrobial resistance and associated resistance mechanisms in P. mirabilIS is warranted.
The Antimicrobial Susceptibility of Klebsiella pneumoniae from Community Settings in Taiwan, a Trend Analysis.
Wu-Pu Lin,Jann-Tay Wang,Jann-Tay Wang,Shan-Chwen Chang,Feng-Yee Chang,Feng-Yee Chang,Chang-Phone Fung,Yin Ching Chuang,Yao-Shen Chen,Yih-Ru Shiau,Mei-Chen Tan,Hui-Ying Wang,Jui-Fen Lai,I-Wen Huang,Tsai-Ling Lauderdale +14 more
TL;DR: Wide genetic diversity is revealed even among the most common sequence type 11 isolates, which means which antibiotics are reasonable empirical therapy options for patients presenting with severe sepsis that might be caused by K. pneumoniae.
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Empiric Therapy With Carbapenem-Sparing Regimens for Bloodstream Infections due to Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae: Results From the INCREMENT Cohort.
Zaira R. Palacios-Baena,Belén Gutiérrez-Gutiérrez,Esther Calbo,Benito Almirante,Pierluigi Viale,Antonio Oliver,Vicente Pintado,Oriol Gasch,Luis Martínez-Martínez,Johann D. D. Pitout,Murat Akova,Carmen Peña,José Molina Gil-Bermejo,Alicia Hernandez,Mario Venditti,Núria Prim,Germán Bou,Evelina Tacconelli,Mario Tumbarello,Axel Hamprecht,Helen Giamarellou,Manel Almela,Federico Perez,Mitchell J. Schwaber,Joaquín Bermejo,Warren Lowman,Po-Ren Hsueh,José Ramón Paño-Pardo,Julián Torre-Cisneros,Maria Souli,Robert A. Bonomo,Yehuda Carmeli,David L. Paterson,Álvaro Pascual,Jesús Rodríguez-Baño,Jorge Galvez,Marco Falcone,Alessandro Russo,George L. Daikos,Enrico Maria Trecarichi,Angela Raffaella Losito,J. Gómez,Elias Iosifidis,Emmanuel Roilides,Ilias Karaiskos,Yohei Doi,Felipe Francisco Tuon,Ferran Navarro,Beatriz Mirelis,José Antonio Martínez,C. de la Calle,L. Morata,R. San Juan,M. Fernández-Ruiz,N. Larrosa,Mireia Puig,José Molina,V. González,V. Rucci,E. Ruiz de Gopegui,C. I. Marinescu,M.C. Fariñas,M. E. Cano,Mónica Gozalo,M. Mora-Rillo,Silvia Gómez-Zorrilla,Fe Tubau,Spyros Pournaras,Athanassios Tsakris,O. Zarkotou,K. Azap,Anastasia Antoniadou,Garyphallia Poulakou,D. Virmani,Cano,Isabel Machuca,Helvaci,A. O. Sahin,Patricia Ruiz-Garbajosa,Michele Bartoletti,Maddalena Giannella,S. Peter,Cristina Badia,M. Xercavins,D. Fontanals,E. Jové +85 more
TL;DR: It was unable to show that empiric treatment with OAD was associated with a worse outcome compared with carbapenems, but information allows more options to be considered for empiric therapy, at least for some patients, depending on local susceptibility patterns of ESBL-E.
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The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs.
TL;DR: In the 1990s, patients who develop SSI have longer and costlier hospitalizations than patients who do not develop such infections, and programs that reduce the incidence of SSI can substantially decrease morbidity and mortality and reduce the economic burden for patients and hospitals.
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Diagnosis and Management of Complicated Intra-abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America
Joseph S. Solomkin,John E. Mazuski,John S. Bradley,Keith A. Rodvold,Ellie J.C. Goldstein,Ellen Jo Baron,Patrick J. O'Neill,Anthony W. Chow,E. Patchen Dellinger,Soumitra R. Eachempati,Sherwood L. Gorbach,Mary Hilfiker,Addison K. May,Avery B. Nathens,Robert G. Sawyer,John G. Bartlett +15 more
TL;DR: These updated guidelines replace those previously published in 2002 and 2003 and add recommendations for managing intra-abdominal infection in children, particularly where such management differs from that of adults; for appendicitis in patients of all ages; and for necrotizing enterocolitis in neonates.
Metallo-β-Lactamases: the Quiet before the Storm?
TL;DR: Their rapid dissemination is worrisome and necessitates the implementation of not just surveillance studies but also metallo-β-lactamase inhibitor studies securing the longevity of important anti-infectives.
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CTX-M: changing the face of ESBLs in Europe
David M. Livermore,Rafael Cantón,Marek Gniadkowski,Patrice Nordmann,Gian Maria Rossolini,Guillaume Arlet,Juan A. Ayala,Teresa M. Coque,Izabela Kern-Zdanowicz,Francesco Luzzaro,Laurent Poirel,Neil Woodford +11 more
TL;DR: Dramatic shifts have occurred in the prevalence and types of extended-spectrum beta-lactamases (ESBLs) in Europe, and changing patterns present major therapeutic and infection control challenges, with the public health intervention points unclear.