Open Access
Supplementary file 3.
Young Seok Ju,Ludmil B. Alexandrov,Moritz Gerstung,Inigo Martincorena,Serena Nik-Zainal,Manasa Ramakrishna,Helen Davies,Elli Papaemmanuil,Gunes Gundem,Adam Shlien,Niccolo Bolli,Sam Behjati,Patrick S. Tarpey,Jyoti Nangalia,Charles E. Massie,Adam Butler,Jon W. Teague,George S. Vassiliou,Anthony R. Green,Ming-Qing Du,Ashwin Unnikrishnan,John E. Pimanda,Bin Tean Teh,Nikhil C. Munshi,Mel Greaves,Paresh Vyas,Adel K. El Naggar,Tom Santarius,V. Peter Collins,Richard Grundy,Jack A. Taylor,D. Neil Hayes,David Malkin,Christopher S. Foster,Anne Y. Warren,Hayley C. Whitaker,Daniel Brewer,Rosalind A. Eeles,Colin Cooper,David E. Neal,Tapio Visakorpi,William B. Isaacs,G. Steven Bova,Adrienne M. Flanagan,P. Andrew Futreal,Andy G. Lynch,Patrick F. Chinnery,Ultan McDermott,Michael R. Stratton,Peter J. Campbell +49 more
- 01 Jan 2014
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TL;DR: All analysed strains originate from single hybridisation event, as most of LOH events are shared by all strains, and some selected duplications and deletions among those longer than 5Kb are represented.
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Abstract: Candida metapsilosis chromosomes graphs For each chromosome we have plotted: i) coding genes for +/-strand (grey bars) and GC-content in 1kb windows (blue plot) in the bottom track and log2 of observed vs expected value in 1kb windows for depth of coverage (blue) in the top fourteen tracks. In the bottom panel, the X axis reflects the genomic position given in bp (from 0 up to 3.25Mb for the longest chromosome), while the Y axis the GC% content (0-100%). In the other panels the Y axis reflect the log2 of observed vs expected depth-of-coverage (from-4 to +4). In addition, loss of heterozygosity (LOH) regions have been marked in grey, if the same genotype as reference was kept (hapA), and orange, if alternative genotype was kept (hapB). Four replicas (pe300, pe600, mp500 and pe400ov) were analysed for PL429. C. metapsilosis genome is a mixture of heterozygous (light grey), haplotype B (dark grey) and haplotype A (orange) regions. We suspect all analysed strains originate from single hybridisation event, as most of LOH events are shared by all strains. Examples of large LOH, duplications and deletions have been annotated ie. rDNA cluster (scaffold5), scaffold5 triploidy in PL448, partial scaffold2 triploidy in SZMC21154 and PL448, and complete LOH in scaffold6 in PL448. For the sake of simplicity, only some selected duplications and deletions among those longer than 5Kb are represented (annotated as such in Supplementary table S4). rDNA cluster is found on the edge of the largest LOH (over 350kb, scaffold5). Interestingly, we have also found rDNA cluster in long (200kb) LOH track in C. orthopsilosis MCO448 (PMID: 24747362).
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Endostatin level is associated with kidney injury in the elderly: findings from two community-based cohorts.
Toralph Ruge,Axel C. Carlsson,Tobias E. Larsson,Juan Jesus Carrero,Anders Larsson,Lars Lind,Johan Ärnlöv +6 more
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Amir Szitenberg,Leontine E. Becking,Leontine E. Becking,Sergio Vargas,Julio C.C. Fernandez,Nadiezhda Santodomingo,Nadiezhda Santodomingo,Gert Wörheide,Micha Ilan,Michelle Kelly,Dorothée Huchon +10 more
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TL;DR: The findings do not support routine prophylactic or therapeutic administration of antiplatelet therapy in pregnancy to all women at increased risk of pre-eclampsia or IUGR, but low-dose aspirin may be justified in women judged to be especially liable to early-onset pre- eClampsia severe enough to need very preterm delivery.
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