Structure-activity relationships

TL;DR: In this paper, a method of generating a diverse set of variants to screen improved and novel properties within the variant population, a system for creating the diverse sets of variants, and the variant peptides was described.

TL;DR: Earlier hypotheses regarding the cause of liver cancer in Africa fail to explain the epidemiologic pattern of this disease, notably its rarity in Egypt.

TL;DR: In this article, methods for building a sequence activity model with reference to structural data, which model can be used to guide directed evolution of proteins having beneficial properties, are presented, and systems and computer program products implementing the methods are also provided.

TL;DR: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reduction enzymes, host cells capable of expressing the engineered reductases, and methods of using these engineered PU with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds as mentioned in this paper.

TL;DR: In this paper, it was shown that the position of the absorption bands of iodine solutions in the visible region moved gradually from violet to brown, the shift being only small in the case of benzene in which the color of iodine is a red-violet.

TL;DR: Miniaturized assays that accommodate extremely low sample volumes and enable the rapid, simultaneous processing of thousands of proteins are developed to facilitate subsequent studies of protein function.

TL;DR: It is of considerable interest that certain inducers of liver microsomal enzymes have recently been used therapeutically for the treatment of hyperbilirubinemia in jaundiced children and for thetreatment of Cushing's syndrome.