Journal Article10.1021/ACS.JNATPROD.5B00272
Structure-Activity Relationship Study on Isothiocyanates: Comparison of TRPA1-Activating Ability between Allyl Isothiocyanate and Specific Flavor Components of Wasabi, Horseradish, and White Mustard
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TL;DR: Allyl isothiocyanate (ITC) is the main pungent component in wasabi, and it generates an acrid sensation by activating TRPA1, and the ITC moiety is likely the predominant contributor to theirTRPA1-activating abilities.
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Abstract: Allyl isothiocyanate (ITC) (4) is the main pungent component in wasabi, and it generates an acrid sensation by activating TRPA1. The flavor and pungency of ITCs vary depending on the compound. However, the differences in activity to activate TRPA1 between ITCs are not known except for a few compounds. To investigate the effect of carbon chain length and substituents of ITCs, the TRPA1-activiting ability of 16 ITCs was measured. Since most of the ITCs showed nearly equal TRPA1-activiting potency, the ITC moiety is likely the predominant contributor to their TRPA1-activating abilities, and contributions of other functional groups to their activities to activate TRPA1 are comparatively small.
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Citations
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease.
Karel Talavera,Justyna B. Startek,Julio Alvarez-Collazo,Brett Boonen,Yeranddy A. Alpizar,Alicia Sanchez,Robbe Naert,Bernd Nilius +7 more
TL;DR: The current knowledge about the mammalian TRPA1 channel is reviewed, linking its unique structure, widely tuned sensory properties and complex regulation to its roles in multiple pathophysiological conditions.
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Bitter taste of Brassica vegetables: The role of genetic factors, receptors, isothiocyanates, glucosinolates, and flavor context.
TL;DR: Interestingly, for some people unpleasant sensations are not perceived, suggesting a potential role of inter-individual variability in bitter taste perception and sensibility.
90
Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies.
Jean Bousquet,Jean Bousquet,Jean-Paul Cristol,Wienczyslawa Czarlewski,Josep M. Antó,Adrian R. Martineau,Tari Haahtela,Susana C. Fonseca,Guido Iaccarino,Hubert Blain,Alessandro Fiocchi,G. Walter Canonica,João Fonseca,Alain Vidal,Hak Jong Choi,Hyun Ju Kim,Vincent Le Moing,Jacques Reynes,Aziz Sheikh,Cezmi A. Akdis,Torsten Zuberbier +20 more
TL;DR: It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity, and it is therefore possible that the intake of these foods may restore an optimal natural balance for the NRF2 pathway.
Modulation of TRPV1 channel function by natural products in the treatment of pain.
TL;DR: Natural products are highly diverse in their modulatory action on TRPV1, and many gaps in natural product research are present in distinguishing modality-specific from polymodal antagonists.
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Localized Excitation of Neural Activity via Rapid Magnetothermal Drug Release
Gabriela Romero,Michael G. Christiansen,Ligia Stocche Barbosa,Ligia Stocche Barbosa,Francisco J. Garcia,Polina Anikeeva +5 more
TL;DR: A thermally labile linker chemistry is adapted for the release of neuromodulatory compounds from the surfaces of MNPs via local nanoscale heating, which triggers Ca2+ influx and action potential firing at particle concentrations three orders of magnitude less than those previously used for magnetothermal neurmodulation accomplished with bulk heating.
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TL;DR: The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Gina M. Story,Andrea M. Peier,Alison J. Reeve,Samer R. Eid,Johannes Mosbacher,Todd R. Hricik,Taryn J. Earley,Anne C. Hergarden,David Andersson,Sun Wook Hwang,Peter McIntyre,Timothy Jegla,Stuart Bevan,Ardem Patapoutian,Ardem Patapoutian +14 more
TL;DR: The characterization of ANKTM1 is described, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8, which is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM 8.
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Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Sven-Eric Jordt,Diana M. Bautista,Huai-hu Chuang,David D. McKemy,Peter M. Zygmunt,Edward D. Högestätt,Ian D. Meng,Ian D. Meng,David Julius +8 more
TL;DR: It is shown that mustard oil depolarizes a subpopulation of primary sensory neurons that are also activated by capsaicin, the pungent ingredient in chilli peppers, and by Δ9-tetrahydrocannabinol, the psychoactive component of marijuana.
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Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
Michael Bandell,Gina M. Story,Sun Wook Hwang,Veena Viswanath,Samer R. Eid,Matt Petrus,Taryn J. Earley,Ardem Patapoutian,Ardem Patapoutian +8 more
TL;DR: It is demonstrated that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain.
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Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
Lindsey J. Macpherson,Adrienne E. Dubin,Michael J. Evans,Felix Marr,Felix Marr,Peter G. Schultz,Peter G. Schultz,Benjamin F. Cravatt,Ardem Patapoutian,Ardem Patapoutian +9 more
TL;DR: In this paper, the authors used click chemistry to show that derivatives of two such compounds, mustard oil and cinnamaldehyde, covalently bind mouse TRPA1 currents that were maintained at least 10 min after washout of the compound in calcium-free solutions.
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