Structural Insight into the Interaction between Platelet Integrin αIIbβ3 and Cytoskeletal Protein Skelemin
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TL;DR: It is shown that skelemin IgC45 domains form a complex not only with integrin β3 CT but also, surprisingly, with the integrin αIIb CT.
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About: This article is published in Journal of Biological Chemistry. The article was published on 02 Nov 2007. and is currently open access. The article focuses on the topics: Integrin, beta 6 & CD49c.
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Tyrosine Phosphorylation as a Conformational Switch A CASE STUDY OF INTEGRIN β3 CYTOPLASMIC TAIL
TL;DR: Under aqueous conditions, the critical Tyr747 phosphorylation prevents β3CT from binding to its heterodimer partner αIIbCT, thus likely maintaining an activated state of the receptor, and these data provide unique molecular insights into multiple regulatory roles ofosphorylation.
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TRAM (Transcriptome Mapper): database-driven creation and analysis of transcriptome maps from multiple sources.
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TL;DR: TRAM is designed to create, and statistically analyze, quantitative transcriptome maps, based on gene expression data from multiple sources, and is able to perform intra-sample and inter-sample data normalization, including an original variant of quantile normalization (scaled quantile), useful to normalize data from platforms with highly different numbers of investigated genes.
Myofibrillogenesis regulator 1 induces hypertrophy by promoting sarcomere organization in neonatal rat cardiomyocytes
TL;DR: Overexpression of MR-1 may induce cardiomyocyte hypertrophy via myomesin-1-mediated sarcomere organization, and the finding that cardiachypertrophy was induced long after increase of sar Comere organization indicates that the promoted sarcomeres organization may be one of the crucial factors causing hyperTrophy.
References
PROCHECK: a program to check the stereochemical quality of protein structures
TL;DR: The PROCHECK suite of programs as mentioned in this paper provides a detailed check on the stereochemistry of a protein structure and provides an assessment of the overall quality of the structure as compared with well refined structures of the same resolution.
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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
Axel T. Brunger,Axel T. Brunger,Paul D. Adams,G M Clore,W. L. DeLano,Piet Gros,R.W. Grosse-Kunstleve,R.W. Grosse-Kunstleve,Jiansheng Jiang,J. Kuszewski,Michael Nilges,Navraj S. Pannu,Randy J. Read,Luke M. Rice,Thomas Simonson,Gregory L. Warren +15 more
TL;DR: The Crystallography & NMR System (CNS) as mentioned in this paper is a software suite for macromolecular structure determination by X-ray crystallography or solution nuclear magnetic resonance (NMR) spectroscopy.
NMRPipe: a multidimensional spectral processing system based on UNIX pipes
TL;DR: The asynchronous pipeline scheme provides other substantial advantages, including high flexibility, favorable processing speeds, choice of both all-in-memory and disk-bound processing, easy adaptation to different data formats, simpler software development and maintenance, and the ability to distribute processing tasks on multi-CPU computers and computer networks.
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