Structural and functional link between the mitochondrial network and the endoplasmic reticulum.

TL;DR: This work reviews the emerging knowledge about the roles of mitochondria in innate immunity and suggests mitochondria appear to function as centrally positioned hubs in the innate immune system.

TL;DR: Optimized protocols to isolate mitochondria-associated membranes, containing unique regions of ER membranes attached to the outer mitochondrial membrane and mitochondria without contamination from other organelles are provided.

TL;DR: The focus of this review is to summarize the current knowledge on the structure and function of Bcl-2 family of proteins in apoptotic cellular processes.

TL;DR: Parl-associated rhomboid-like (PARL-like) as mentioned in this paper is an inner mitochondrial membrane rhomboids of unknown function, whose yeast ortholog is involved in mitochondrial fusion.

TL;DR: It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.

TL;DR: The spatial relation between mitochondria and endoplasmic reticulum in living HeLa cells was analyzed at high resolution in three dimensions with two differently colored, specifically targeted green fluorescent proteins to emphasize the importance of cell architecture and the distribution of organelles in regulation of Ca2+ signaling.

TL;DR: Recent work is discussed that suggests that the dynamics (fusion and fission) of these organelles is important in development and disease.

TL;DR: It is shown that mutations in the human dynamin-related protein Drp1 cause mitochondria to form perinuclear clusters that consist of highly interconnected mitochondrial tubules, which indicates that the balance between mitochondrial division and fusion is shifted toward fusion.