Journal Article10.1088/0960-1317/21/5/054015
Stretchable microelectrode array using room- temperature liquid alloy interconnects
Pinghung Wei,Rebecca E. Taylor,Zhenwen Ding,Cindy Chung,Oscar J. Abilez,G. Higgs,Beth L. Pruitt,Babak Ziaie +7 more
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TL;DR: In this paper, a stretchable microelectrode array for studying cell behavior under mechanical strain was presented, which consists of gold-plated nail-head pins (250 µm tip diameter) or tungsten micro-wires (25.4 µm in diameter) inserted into a polydimethylsiloxane (PDMS) platform.
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Abstract: In this paper, we present a stretchable microelectrode array for studying cell behavior under mechanical strain. The electrode array consists of gold-plated nail-head pins (250 µm tip diameter) or tungsten micro-wires (25.4 µm in diameter) inserted into a polydimethylsiloxane (PDMS) platform (25.4 × 25.4 mm2). Stretchable interconnects to the outside were provided by fusible indium-alloy-filled microchannels. The alloy is liquid at room temperature, thus providing the necessary stretchability and electrical conductivity. The electrode platform can withstand strains of up to 40% and repeated (100 times) strains of up to 35% did not cause any failure in the electrodes or the PDMS substrate. We confirmed biocompatibility of short-term culture, and using the gold pin device, we demonstrated electric field pacing of adult murine heart cells. Further, using the tungsten microelectrode device, we successfully measured depolarizations of differentiated murine heart cells from embryoid body clusters.
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Citations
Microsystems for biomimetic stimulation of cardiac cells
TL;DR: The electromechanical environment of the heart is described and MEMS specifically designed to replicate these stimulation modes are discussed for a variety of applications.
52
A novel stretchable micro-electrode array (SMEA) design for directional stretching of cells
TL;DR: In this article, a pneumatically actuated stretchable micro-electrode arrays (SMEAs) are presented to achieve stretchability with minimal surface area dedicated to the electrical interconnects and a well-defined surface strain distribution combined with integrated diverse micro-patterns to enable alignment and directional stretching of cells.
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A Stretchable Microneedle Electrode Array for Stimulating and Measuring Intramuscular Electromyographic Activity
Gareth S. Guvanasen,Liang Guo,Ricardo Aguilar,Ashton L. Cheek,Chancellor S. Shafor,Swaminathan Rajaraman,T. Richard Nichols,Stephen P. DeWeerth +7 more
- 01 Sep 2017
TL;DR: A stretchablemicroneedle electrode array (sMEA) to stimulate and measure the electrical activity of muscle across multiple sites and has direct application to wearable sensors, neuroprostheses, and electrophysiological studies of animals and humans.
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Patent
Pdms-based stretchable multi-electrode and chemotrode array for epidural and subdural neuronal recording, electrical stimulation and drug delivery
Janos Vörös,Grégoire Courtine,Alexandre Larmagnac,Pavel Musienko +3 more
- 14 Jun 2011
TL;DR: In this article, an implantable device for the electrical and/or pharmaceutical stimulation of the central nervous system, especially the spinal cord, is suggested, which comprises a conformable substrate which is primarily composed of a flexible and stretchable polymer, and a plurality of flexible electrodes and conductive leads embedded in the conformable substrategies.
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Planar patterned stretchable electrode arrays based on flexible printed circuits
TL;DR: A new strategy for creating planar stretchable electronics is presented and a stretchable microelectrode array based on flex circuit technology is demonstrated, achieving constant resistances for strains up to 20% with less than a 4% resistance offset over 120,000 cycles at 10% strain.
References
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TL;DR: In this article, the impact of substrate mechanical properties on cell adhesion and motility was investigated by modifying bulk rigidity, surface energy and composition of a bio-compatible poly-di-methyl-siloxane (PDMS) substrate.
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Thickness-dependent mechanical properties of polydimethylsiloxane membranes
TL;DR: In this article, the authors demonstrate that both the mechanical strength and the Young's modulus of polydimethylsiloxane (PDMS) membranes are thickness dependent and the transition from bulk behavior to dimension dependent is predicted to occur at a membrane thickness of about 200 µm.
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A realistic brain tissue phantom for intraparenchymal infusion studies
Zhi Jian Chen,George T. Gillies,William C. Broaddus,Sujit S. Prabhu,Helen L. Fillmore,Ryan M. Mitchell,Frank D. Corwin,Panos P. Fatouros +7 more
TL;DR: Agarose gel (0.6%) is a useful surrogate for in vivo brain in exploratory studies of convection-enhanced delivery in preclinical and exploratory Studies of infusion-based intraparenchymal drug and cell delivery.
325
Flexible and stretchable micro-electrodes for in vitro and in vivo neural interfaces
Stéphanie P. Lacour,Samia Benmerah,E.J. Tarte,James J. FitzGerald,Jordi Serra,Stephen B. McMahon,James W. Fawcett,Oliver Graudejus,Zhe Yu,Barclay Morrison +9 more
TL;DR: A material strategy to prepare neural electrodes with improved mechanical compliance that relies on thin metal film electrodes embedded in polymeric substrates is described.
Stretchable micro-electrode array [for retinal prosthesis]
Mariam Maghribi,Julie Hamilton,Dennis L. Polla,Klint A. Rose,Thomas S. Wilson,Peter Krulevitch +5 more
- 07 Aug 2002
TL;DR: In this article, an implantable, stretchable micro-electrode array using polymer-based microfabrication techniques was developed to stimulate retinal neurons via thin film conducting traces and electroplated electrodes.
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