Stress-induced EGF receptor signaling through STAT3 and tumor progression in triple-negative breast cancer
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TL;DR: This review discusses how STAT3 signaling induced by therapeutic stress in EGFR-driven triple-negative breast cancers (TNBC) might override normal epithelial homeostatic mechanisms and provide a survival advantage for tumor cells before they leave the primary tumor and spread to distant sites.
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About: This article is published in Molecular and Cellular Endocrinology. The article was published on 15 Aug 2017. and is currently open access. The article focuses on the topics: Tumor progression & Primary tumor.
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TL;DR: The ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity.