Stem Cells Down Under—ISSCR 2007
Stuart H. Orkin,Martin F. Pera +1 more
TL;DR: Some of the newest findings from the ISSCR meeting are reviewed in an effort to convey the energy and excitement of the meeting and the tempo of stem cell science.
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About: This article is published in Cell Stem Cell. The article was published on 13 Sep 2007. and is currently open access.
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Citations
Bioreactor cultivation enhances NTEB formation and differentiation of NTES cells into cardiomyocytes.
Shuanghong Lü,Sheng Liu,Wenjun He,Cuimi Duan,Yanmin Li,Zhiqiang Liu,Ye Zhang,Tong Hao,Yanmeng Wang,Dexue Li,Changyong Wang,Shaorong Gao +11 more
TL;DR: It is suggested that STLV bioreactor provided a more ideal culture condition, which can facilitate the formation of better quality NTEBs and differentiation into cardiomyocytes more efficiently in vitro.
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Early Hematopoietic Differentiation in Acute Lymphoblastic Leukemia: The Interplay Between Leukemia-Initiating Cells and Abnormal Bone Marrow Microenvironment
Armando Vilchis-Ordoñez,Elisa Dorantes-Acosta,Eduardo Vadillo,Briceida López-Martínez,Rosana Pelayo +4 more
- 01 Jan 2016
TL;DR: By unraveling the role of leukemic precursor cells in the initiation of local inflammatory processes leading to hematopoietic instability, additional mechanisms co-participating in the etiology and maintenance of this pathological condition are learned.
7
Embryonic stem cells - current knowledge and future prospects
J. Slamečka,P. ChrEnEK +1 more
- 01 Jan 2010
TL;DR: In this paper, the authors discuss categories according to the differentiation potential or plasticity of stem cells which is closely intertwined with their developmental rank in mammals ranging from totipotent zygote to monopotent stem cells.
The 5th International Society for Stem Cell Research (ISSCR) Annual Meeting, June 2007.
TL;DR: This report presents highlights of discussions that focused on the biology of cancer stem cells as conducted at the fifth Annual Meeting of the International Society for Stem Cell Research, held in Cairns, Australia, June 17–20, 2007.
References
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
TL;DR: Induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions is demonstrated and iPS cells, designated iPS, exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
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Pluripotency of mesenchymal stem cells derived from adult marrow
Yuehua Jiang,Balkrishna N. Jahagirdar,R. Lee Reinhardt,Robert E. Schwartz,C. Dirk Keene,Xilma R. Ortiz-Gonzalez,Morayma Reyes,Todd Lenvik,Troy C. Lund,Mark Blackstad,Jingbo Du,Sara Aldrich,Aaron Lisberg,Walter C. Low,David A. Largaespada,Catherine M. Verfaillie +15 more
TL;DR: It is reported here that cells co-purifying with mesenchymal stem cells—termed here multipotent adult progenitor cells or MAPCs—differentiate, at the single cell level, not only into meschymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro.
A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells
Bradley E. Bernstein,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Xiaohui Xie,Michael Kamal,Dana J. Huebert,James Cuff,Ben Fry,Alexander Meissner,Marius Wernig,Kathrin Plath,Rudolf Jaenisch,Alexandre Wagschal,Robert Feil,Stuart L. Schreiber,Stuart L. Schreiber,Eric S. Lander,Eric S. Lander +17 more
TL;DR: It is proposed that bivalent domains silence developmental genes in ES cells while keeping them poised for activation, highlighting the importance of DNA sequence in defining the initial epigenetic landscape and suggesting a novel chromatin-based mechanism for maintaining pluripotency.
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Core transcriptional regulatory circuitry in human embryonic stem cells.
Laurie A. Boyer,Tong Ihn Lee,Megan F. Cole,Sarah E. Johnstone,Stuart S. Levine,Jacob P. Zucker,Matthew G. Guenther,Roshan M. Kumar,Heather L. Murray,Richard G. Jenner,David K. Gifford,David K. Gifford,David K. Gifford,Douglas A. Melton,Douglas A. Melton,Rudolf Jaenisch,Richard A. Young,Richard A. Young +17 more
TL;DR: Insight is provided into the transcriptional regulation of stem cells and how OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal and how they collaborate to form regulatory circuitry consisting of autoregulatory and feedforward loops.
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Generation of germline-competent induced pluripotent stem cells
TL;DR: iPS cells competent for germline chimaeras can be obtained from fibroblasts, but retroviral introduction of c-Myc should be avoided for clinical application.
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