Patent
Stable insulin formulations
Michael Rosario Defelippis,Michael Allen Dobbins,Bruce H. Frank,Shun Carmel Li,Dawn Marie Rebhun +4 more
- 12 Jun 1998
152
TL;DR: In this article, a monomeric insulin analog formulation stabilized against aggregation in which the buffering agent is either TRIS or arginine was presented, and the stable formulations of the present invention are useful for treating diabetes.
read more
Abstract: The present invention provides a monomeric insulin analog formulation stabilized against aggregation in which the buffering agent is either TRIS or arginine. The stable formulations of the present invention are useful for treating diabetes, and are particularly advantageous in treatment regimes requiring lengthy chemical and physical stability, such as, in continuous infusion systems.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Patent
Infusion pump system with disposable cartridge having pressure venting and pressure feedback
Michael Michaud,Geoffrey A. Kruse +1 more
- 29 Jul 2010
TL;DR: In this article, the authors describe portable infusion devices, systems, and methods of using the same for dispensing materials, e.g., insulin, into a body in need of it.
245
Patent
Soluble tumor necrosis factor receptor treatment of medical disorders
Barbara K. Finck
- 19 Apr 2000
TL;DR: In this paper, the authors describe methods and compositions for treating medical disorders characterized by elevated levels or abnormal expression of TNFα by administering a tNFα antagonist, such as recombinant TNF:Fc.
192
Patent
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
Nnochiri N. Ekwuribe,Christopher H. Price,Aslam M. Ansari,Amy L. Odenbaugh +3 more
- 04 Jun 2002
TL;DR: A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed as mentioned in this paper.
145
Patent
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
Frank Himmelsbach,Elke Langkopf,Matthias Eckhardt,Michael Mark,Roland Maier,Ralf Lotz,Mohammad Tadayyon +6 more
- 20 Jun 2008
TL;DR: In this paper, substituted xanthines of general formula R 1 to R 3 are defined as the tautomers, stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties.
132
Patent
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
Richard Soltero,Nnochiri N. Ekwuribe,Foyeke Opawale,Bruce Rehlaender,Anthony Hickey,Li Li Bovet +5 more
- 06 Sep 2002
TL;DR: In this article, an insulin drug-oligomeric conjugate, a fatty acid component, and a bile salt component are described, and methods of treating an insulin deficiency in a subject in need of such treatment using such pharmaceutical compositions are also provided.
111
References
Patent
Therapeutic preparation for inhalation
Kjell Bäckström,Dahlbaeck Carl Magnus Olof,Peter Edman,Johansson Ann Charlotte Birgit +3 more
- 23 Jun 1994
TL;DR: A therapeutic preparation for inhalation which comprises insulin and a substance which enhances the absorption of insulin in the lower respiratory tract, is provided in the form of a powder preparation suitable for inhaling.
229
Patent
Insulin analog formulations
Diane Lee Bakaysa,David N. Brems,Bruce H. Frank,Henry A. Havel,Allen H. Pekar +4 more
- 07 Sep 1995
TL;DR: In this paper, various parenteral pharmaceutical formulations, which comprise a mixture of a monomeric insulin analog and insulin-NPH, are described. But none of these formulations provide a rapid onset and a prolonged duration of action.
168
Patent
Insulin analogues and method of preparing the same
Jens Jorgen Veilgaard Brange,Norris Kjeld,Mogens Trier Hansen +2 more
- 29 Aug 1986
TL;DR: In this article, a rapid-acting human insulin analog is provided having less tendency to self-association into dimers, tetramers, hexamers, or polymers.
154
Patent
Insulin analogs modified at position 29 of the B chain
Ronald E. Chance,Richard D. DiMarchi,Frank Bruce Hill,James E. Shields +3 more
- 05 May 1993
TL;DR: Analogs of human insulin modified at position 29 of the B chain thereof and, optionally, at other positions, have modified physico-chemical and pharmacokinetic properties and are useful in the treatment of hyperglycemia as discussed by the authors.
135
•Journal Article
Chemical stability of insulin. 3: Influence of excipients, formulation, and pH
Brange J,Langkjaer L +1 more
TL;DR: In this paper, the influence of auxiliary substances and pH on the chemical transformations of insulin in pharmaceutical formulation, including various hydrolytic and intermolecular cross-linking reactions, was studied.
123