Specific decrease of secretin/VIP-stimulated adenylate cyclase in the heart from the Lyon strain of hypertensive rats.
Patrick Robberecht,L. Gillet,Pierre Chatelain,P. De Neef,Jean Claude Camus,M. Vincent,J. Sassard,Jean Christophe +7 more
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TL;DR: The major finding was a 30-35% decrease of secretin- and VIP-stimulated adenylate cyclase activity in cardiac membranes of LH rats that was already obvious in 5 week-old prehypertensive animals, and it is tempting to conclude that a selective alteration of functional cardiac secretin/VIP receptors in LH rats reflects a local hyperactivity of the sympathetic adrenergic system.
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About: This article is published in Peptides. The article was published on 01 Mar 1984. and is currently open access. The article focuses on the topics: Cyclase activity & Cyclase.
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Citations
Genesis and Regulation of the Heart Automaticity
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TL;DR: Evidence on the functional role of different families of ion channels in cardiac pacemaking is discussed and recent results obtained on genetically engineered mouse strains displaying dysfunction in heart automaticity are reviewed.
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The physiological roles of secretin and its receptor
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TL;DR: The role of secretin and its receptor in health and biliary disease pathogenesis, and future areas of research for the further evaluation of the secretin/secretin receptor axis in liver pathophysiology are proposed.
Heart receptors for VIP, PHI and secretin are able to activate adenylate cyclase and to mediate inotropic and chronotropic effects. Species variations and physiopathology
TL;DR: Findings are consistent with a hyperactivity of norepinephrine pathways in spontaneously hypertensive rats, leading to a reduced number of cardiac post-junctional secretin/VIP receptors bound to adenylate cyclase.
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Vasoactive intestinal peptide in the heart.
TL;DR: Among the neuropeptides exerting a neurotransmitter function on the autonomic nervous system and involved in the regulation of heart function and smooth vascular tone, vasoactive intestinal polypeptide ( and the related peptide histidineisoleucine (PHI)' are of particular importance.
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Alterations of rat cardiac adenylate cyclase activity with age
Patrick Robberecht,Michel Gillard,Magali Waelbroeck,Jean Claude Camus,Philippe De Neef,Jean Christophe +5 more
TL;DR: Results suggest an alteration with age in the vicinity of the catalytic unit of adenylate cyclase and a selective decrease of functional glucagon and secretin receptors.
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References
A Highly Sensitive Adenylate Cyclase Assay
TL;DR: The high sensitivity of this method permits detection of the small amounts of cyclic AMP formed at low enzyme concentrations or at early time points in kinetic studies.
4.2K
Secretin and VIP-stimulated adenylate cyclase from rat heart. I. General properties and structural requirements for enzyme activation
Pierre Chatelain,Patrick Robberecht,De Neef P,Monique Deschodt-Lanckman,W. König,Jean Christophe +5 more
TL;DR: In this paper, the half-maximal adenylate cyclase activation with glucagon, secretin, and VIP was achieved at concentrations of 0.5, 0.1 mM, and 1.0 μM, respectively.
Early increase in phenylethanolamine-N-methyltransferase activity in a new strain of spontaneously hypertensive rats
Bernard Renaud,Soizic Fournie`re,Luc Denoroy,Madeleine Vincent,Jean-Franç¸ois Pujol,J. Sassard +5 more
TL;DR: In young rats of the hypertensive strain, there was an increase in the capacity to synthetize adrenaline in the C2 area of the medulla oblongata and in the adrenal glands, a characteristic common to at least two independently derived strains of genetically hypertensive rats.
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Early decrease in secretin-, glucagon-, and isoproterenol-stimulated cardiac adenylate cyclase activity in rats treated with isoproterenol
TL;DR: A complex pattern of adenylate cyclase desensitization in heart membranes from animals chronically treated with D,L-isoproterenol is reminiscent of that observed in heart membrane from spontaneously hypertensive rats.
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Low responsiveness of cardiac adenylate cyclase activity to peptide hormones in spontaneously hypertensive rats
TL;DR: The stimulation of adenylate cyclase activity in stable, highly responsive preparations of cardiac membranes from spontaneously (genetic) hypertensive SH rats, renal hypertensive rats of the Goldblatt type, and their no~otensive controls is compared.
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