Journal Article10.1038/s41467-023-39447-9
Spatial Transcriptomics-correlated Electron Microscopy maps transcriptional and ultrastructural responses to brain injury
Peter Androvic,Martina Schifferer,Ludovico Cantuti-Castelvetri,Hanyi Jiang,Hao Ji,Lu Liu,Garyfallia Gouna,Stefan A. Berghoff,Johanna Knoferle,Mikael Simons,Ozgun Gokce +10 more
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Aixin Zhang,L.M. Jin,Shenqin Yao,Makoto Matsuyama,Cindy T. J. van Velthoven,Heather A. Sullivan,Na Sun,Manolis Kellis,Bosiljka Tasic,Ian R. Wickersham,Xiaoyin Chen +10 more
TL;DR: In this article , the authors combined barcoded rabies virus with single-cell and in situ sequencing to perform retrograde labeling and transsynaptic labeling in the mouse brain and identified long-range projecting cortical cell types from multiple cortical areas and identified cell types with converging or diverging synaptic connectivity.
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Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
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Label-Free Techniques for Probing Biomolecular Condensates.
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Microglia as integrators of brain-associated molecular patterns.
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A practical guide to spatial transcriptomics.
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Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.
Takahiro Masuda,Roman Sankowski,Ori Staszewski,Chotima Böttcher,Lukas Amann,Sagar,Christian Scheiwe,Stefan Nessler,Patrik Kunz,Geert van Loo,Volker A. Coenen,Peter C. Reinacher,Anna Michel,Ulrich Sure,Ralf Gold,Dominic Grün,Josef Priller,Josef Priller,Christine Stadelmann,Marco Prinz +19 more
TL;DR: Insight is provided into the endogenous immune system of the central nervous system during development, homeostasis and disease, and may also provide new targets for the treatment of neurodegenerative and neuroinflammatory pathologies.