Solvent Induced Disulfide Bond Formation in 2,5-dimercapto-1,3,4-thiadiazole
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TL;DR: In this paper, the authors found that disulfide bond formation takes place between two sulfhydryl groups of DMcT molecules in methanol and proposed a mechanism for solvent induced disulfides bond formation on the basis of the results obtained.
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Abstract: Disulfide bond formation is the decisive event in the protein folding to determine the conformation and stability of protein. To achieve this disulfide bond formation in vitro, we took 2,5-dimercapto-1,3,4-thiadiazole (DMcT) as a model compound. We found that disulfide bond formation takes place between two sulfhydryl groups of DMcT molecules in methanol. UV-Vis, FT-IR and mass spectroscopic as well as cyclic voltammetry were used to monitor the course of reaction. We proposed a mechanism for the solvent induced disulfide bond formation on the basis of the results we obtained.
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Systems, compositions, and methods for corrosion inhibition
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TL;DR: Corrosion inhibition systems, including coated substrates, coating materials and corrosion inhibition compounds, and methods of making the same are disclosed in this article, where the active inhibitor groups are selected to block corrosion at the surface by inhibiting oxidation reactions, reduction reactions and/or by forming a passivation layer.
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