Journal Article10.1080/01483918708066820
Solvatochromic Measurements of Mobile Phase Composition in Reversed Phase Liquid Chromatography: Polarity Values, Retention, and Stationary Phase Information
John G. Dorsey,Bruce P. Johnson +1 more
31
TL;DR: The ET(30) polarity values of binary methanol-water, acetonitrile-water and tetrahydrofuran-water mobile phases used in reversed phase liquid chromatography are reported in this article.
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Abstract: The ET(30) polarity values of binary methanol-water, acetonitrile-water and tetrahydrofuran-water mobile phases used in reversed phase liquid chromatography are reported, and equations are presented for the calculation of polarity values for any composition of these solvents. We summarize previously reported comparisons of these measured polarities with both chromatographic retention and methylene selectivity. Plots of log k' vs. ET(30) polarity were generally found to be better descriptors of retention than commonly used plots of log k' vs. percent organic modifier. For 332 data sets examined, the average r2 value for plotting log k' vs. percent organic modifier was 0.9783 while plotting vs. ET(30) polarity gave a value of 0.9910. Retention in acetonitrile-water mixtures is also compared with theory developed by Dill using binary interaction parameters. Variation in methylene selectivity was found to correlate best with percent organic modifier in methanol-water mixtures, while the ET(30) polari...
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Citations
Partition and displacement models in reversed-phase liquid chromatography with mixed eluents
TL;DR: In this article, a simplified version of this model, which represents the formation of the solvent surface stationary phase via a displacement mechanism and the distribution of the solute between the mobile and stationary phases via a partition mechanism, is discussed in order to demonstrate its utility for characterizing RPLC systems.
124
Global linear solvation energy relationships for retention prediction in reversed-phase liquid chromatography
TL;DR: A global linear solvation energy relationship (LSER) that simultaneously models retention in reversed-phase liquid chromatography as a function of both solute LSER descriptors and mobile phase composition has been derived from both the local LSER model and the linear solvent strength theory (LSST) as discussed by the authors.
94
Solvatochromic hydrogen bond donor acidity of aqueous binary solvent mixtures for reversed-phase liquid
TL;DR: In this article, the authors measured the solvatochromic hydrogen bond (HB) donor acidity (αm) values for aqueous mixtures of methanol, ethanol, isopropanol, acetonitrile and tetrahydrofuran.
79
Influence of eluent composition on retention and selectivity of alkylamide phases under reversed-phase conditions
TL;DR: In this paper, the sorption properties of alkylamide phases have been studied under reversed-phase conditions using different compositions of methanol-water as eluents, and it has been demonstrated that the composition of solvents in the stationary phase can be changed significantly by the presence of a specific interaction site in the bonded ligands.
63
References
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High-Performance Liquid Chromatography: Advances and Perspectives
Csaba Horváth
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TL;DR: In this paper, the authors suggest to spend a few moment to read a book, even only few pages, even if it is not obligation and force for everybody, reading book becomes a choice of your different characteristics.
499
Role of organic modifier sorption on retention phenomena in reversed-phase liquid chromatography
R. M. McCormick,Barry L. Karger +1 more
TL;DR: In this article, distribution phenomena associated with the elution of solutes of varying retention from reversed-phase chromatographic columns have been examined, and it was shown that the composition of the extracted modifier system could be varied by the addition of a second solvent to the mobile phase, such as occurs in ternary mobile phase systems.
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