Solid Dosage Forms: Formulation and Characterization

TL;DR: It is shown that resistance exercise, coupled with adequate energy intake (shown by maintenance of body mass determined by dual‐energy X‐ray absorptiometry [DXA]) and vitamin D, can maintain bone in most regions during 4‐ to 6‐month missions in microgravity.

TL;DR: This review focuses on the recent progress in the granulation techniques and technologies such as pneumatic drygranulation, reverse wet granulation, steam granulations, moisture-activated dry granule, thermal adhesion granulation; and foamed binder or foam granulation.

TL;DR: Sleep deficiency in astronauts was prevalent not only during space shuttle and ISS missions, but also throughout a 3 month preflight training interval, and use of sleep-promoting drugs was pervasive during spaceflight.

TL;DR: It is proposed that transcapillary fluid shifts in microgravity may be related to the loss of tissue weight and external compression of blood vessels and future studies should improve hardware and protocols to protect crew members during prolonged missions.