Patent
Skin probiotic formulation
Thomas Hitchcock,Mun Su Rhee +1 more
- 24 Feb 2017
4
TL;DR: In this article, the growth and viability of such genetically modified microbes can optionally be controlled by inducible promoters that regulate the expression of proteins that are essential to their growth and survival.
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Abstract: Microbes can be genetically modified to express biomolecules that are beneficial to mammals and/or to reduce, or eliminate, expression of harmful virulence factors. The growth and viability of such genetically modified microbes can optionally be controlled by inducible promoters that regulate the expression of proteins that are essential to their growth and survival. Compositions comprising such genetically modified microbes as well as methods of making and using the same are disclosed herein.
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Citations
Patent
Methods and compositions for changing the composition of the skin microbiome using complex mixtures of bacterial strains
Bernhard Pätzold,Marc Güell +1 more
- 20 Apr 2016
TL;DR: In this article, the authors describe compositions comprising one or more live bacterial strains for topical administration to the skin, wherein the one or multiple live bacterial strain are Propionibacterium acnes (P. acnes ) bacterial strains, and methods for use.
11
Patent
Compositions and methods for treating skin diseases and maintaining healthy skin
Huiying Li,Emma Barnard,Baochen Shi +2 more
- 07 Nov 2017
TL;DR: In this paper, the authors present methods and compositions for the treatment or prevention of a skin disease (e.g., acne) in a subject by administering to the subject a composition comprising a strain of P. granulosum, a strain OF P. avidum, and/or a strain Of P. humerusii.
4
Patent
Recombinant type I CRISPR-Cas system
Rodolphe Barrangou,Claudio Hidalgo-Cantabrana +1 more
- 25 Sep 2019
TL;DR: In this paper, the authors describe recombinant Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) arrays and recombinant nucleic acid constructs encoding Type I-E CASCADE complexes as well as plasmids, retroviruses and bacteriophage comprising the same.
2
Patent
Recombinant type i crispr-cas system and uses thereof for genome modification and alteration of expression
Barrangou Rodolphe,Cantabrana Claudio Hidalgo +1 more
- 09 Apr 2020
TL;DR: In this paper, a method for modifying the genome of target organisms using recombinant Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) arrays and recombinant nucleic acid constructs encoding Type 1-E CASCADE complexes is described.
1
References
Purification, Characterization, and Heterologous Expression in Fusarium venenatum of a Novel Serine Carboxypeptidase from Aspergillus oryzae
TL;DR: A novel serine carboxypeptidase (EC 3.4.1) was found in an Aspergillus oryzae fermentation broth and was purified to homogeneity and produced two bands which had molecular weights greater than the molecular weight of the native carboxypespsidase from A. oryzAE.
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Patent
Genetically modified bacteria and methods for genetic modification of bacteria
Thomas Hitchcock,Mun Su Rhee +1 more
- 17 Jun 2015
TL;DR: In this paper, the growth and viability of such genetically modified microbes can optionally be controlled by inducible promoters that regulate the expression of proteins that are essential to their growth and survival.
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Patent
Methods of using interleukin-1 receptor antagonist as a myeloprotective agent
Wei Han,Jing Zhang,Di Xiang,Shunying Zhu +3 more
- 14 Nov 2007
TL;DR: The use of interleukin-1 receptor antagonist (IL-1Ra) in promoting bone marrow regeneration, increasing peripheral white blood cells, and increasing platelet levels in subjects if administered prior to treatment with chemotherapeutic agents is discussed in this paper.
5
Patent
Product containing living probiotic microorganisms
Maximilian Emanuel May
- 16 Jan 2008
TL;DR: In this article, a liquid fermented natural product which contains live probiotic microorganisms in an amount of 10 5 to 10 15 cells/ml, wherein the fraction of dead microorganisms is present in excess, and also a process for producing this natural product, and a vessel for storage thereof.
3
Patent
Improved host cell for producing proteins
Cédric Szpirer,Cavrenne Jonathan,Benjamin Michel +2 more
- 24 Jul 2015
TL;DR: In this paper, a host cell for producing a recombinant peptide, polypeptide or protein of interest, wherein said host cell comprises at least 2 copies of a nucleic acid sequence encoding a poison protein, was described.
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