Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15).

TL;DR: This review covers the current understanding of the role of HOX genes in normal hematopoiesis, AML and ALL, with particular emphasis on the similarities and differences ofHOX function in these contexts, their hematoietic downstream gene targets and implications for therapy.

TL;DR: In this paper, the NUP98-HOXD13 fusion gene was shown to promote growth and impaired differentiation of early hematopoietic progenitor cells in vitro.

TL;DR: This work discusses the four nucleoporins that have been linked to cancers, either through elevated expression in tumors or through involvement in chromosomal translocations that encode chimeric fusion proteins.

TL;DR: A new recurrent chromosomal inversion of chromosome 7, inv(7)(p15q34), is described in a subset of patients with T-cell acute lymphoblastic leukemia characterized by CD2 negative and CD4 positive, CD8 negative blasts, in keeping with a previous report suggesting HOXA deregulation in MLL-rearranged T- and B cell lymphoblasts as the key factor in leukaemic transformation.

TL;DR: Fusion proteins formed after chromosomal translocations are common in a range of tumour types; these are unique tumour antigens and are therefore potential targets for therapy design.

TL;DR: Cooperative and antagonistic effects integrated at regulatory elements are likely to be important for specificity and for finely tuned differences in cell-type-specific alternative splicing patterns.

TL;DR: The differential expression of a number of genes that undergo alternative poly(A) site choice or polyadenylation/splicing competition could be regulated at the level of amounts and activities of either generic or tissue-specific polyadenyation factors and/or splicing factors.

TL;DR: This study shows that in three patients with t(7;11), the chromosome rearrangement creates a genomic fusion between the HOXA9 gene and the nucleoporin gene NUP98 on chromosome 11 p15, which is identified as an important human myeloid leukaemia gene.