Simple engineering of hybrid cellulose nanocrystal-gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties.
Giacomo Biagiotti,Gianluca Toniolo,Martin Albino,Mirko Severi,Patrizia Andreozzi,Marcello Marelli,Hana Kokot,Giancarlo Tria,Annalisa Guerri,Claudio Sangregorio,Javier Rojo,Debora Berti,Marco Marradi,Stefano Cicchi,Iztok Urbančič,Yvette van Kooyk,Fabrizio Chiodo,Barbara Richichi +17 more
TL;DR: In this paper , a modular glyconanomaterial whose surface is then easily engineered with one or two different headgroups, by exploiting a robust click chemistry route, is presented, showing that the sugars retain their binding capability to C-type lectin receptors, as also directly visualized by cryo-TEM.
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Abstract: Cellulose nanocrystal and gold nanoparticles are assembled, in a unique way, to yield a novel modular glyconanomaterial whose surface is then easily engineered with one or two different headgroups, by exploiting a robust click chemistry route. We demonstrate the potential of this approach by conjugating monosaccharide headgroups to the glyconanomaterial and show that the sugars retain their binding capability to C-type lectin receptors, as also directly visualized by cryo-TEM.
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Citations
Responsive Regulation of Energy Transfer in Lanthanide‐Doped Nanomaterials Dispersed in Chiral Nematic Structure
Yuxia Luo,Qingdi Liu,Ping He,Liang Li,Zhao Zhang,Xinping Li,Guochen Bao,Ka‐Leung Wong,Peter A. Tanner,L. L. Jiang +9 more
TL;DR: Responsive regulation of energy transfer in lanthanide-doped nanomaterials dispersed in chiral nematic structure. The mechanisms of energy transfer and the photonic effect of chiral nematic structures on energy transfer are introduced.
4
Shaping Silver Nanoparticles’ Size through the Carrier Composition: Synthesis and Antimicrobial Activity
Margherita Cacaci,Giacomo Biagiotti,Gianluca Toniolo,Martin Albino,Claudio Sangregorio,Mirko Severi,Maura Di Vito,Damiano Squitieri,Luca Contiero,Marco Paggi,Marcello Marelli,Stefano Cicchi,Francesca Bugli,Barbara Richichi +13 more
TL;DR: In this article , the synthesis of three different silver nanoparticles (AgNPs) hybrids using both organic and inorganic supports with intrinsic antibacterial properties is described, and tuning of the AgNPs shape and size according to the type of bioactive support is also investigated.
Biocompatible Cellulose Nanocrystal-Based Trojan Horse Enables Targeted Delivery of Nano Au Radiosensitizers to Triple Negative Breast Cancer Cells
Giacomo Biagiotti,Riccardo Cazzoli,Patrizia Andreozzi,Giusi Aresta,Mattii Francesco,Chiara Mangini,Paolo Di Gianvincenzo,Chiara Tobia,Sandro Recchia,Laura Polito,Mirko Severi,Orazio Vittorio,Stefano Cicchi,S. E. Moya,Roberto Ronca,Adriana Albini,Debora Berti,Roberto Orecchia,Cristina Garibaldi,Saverio Minucci,Barbara Richichi +20 more
TL;DR: Biocompatible cellulose nanocrystal-based Trojan horse enables targeted delivery of nano Au radiosensitizers to triple negative breast cancer cells.
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