Journal Article10.1016/J.SNA.2006.02.038
Si technology based microinductive devices for biodetection applications
Christophe Serre,S. Martinez,Alejandro Pérez-Rodríguez,Joan Ramon Morante,Jaume Esteve,Josep Montserrat +5 more
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TL;DR: In this article, the authors presented the design and fabrication of inductive devices integrated in Si technology aimed at high sensitivity biodetection applications, which are based on the changes of the coil inductance due to the presence of magnetic particles in the active region of the device.
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Abstract: This work presents the design and fabrication of inductive devices integrated in Si technology aimed at high sensitivity biodetection applications. The sensing principle is based on the changes of the coil inductance due to the presence of magnetic particles in the active region of the device. These particles act as markers of the biological molecule to be detected. For the simulation of the devices, a very simple finite elements model has been developed. To increase the device sensibility to the presence of the magnetic particles, a magnetic layer has been locally deposited on the back of the substrate in the region of the coils. The analysis of these devices has shown their ability to detect a minimum amount of 110 magnetic particles fixed on an 0.8 mm 2 active area, which gives an estimation of the detection limit of the devices of about 4 × 10 −14 M. This corroborates the potential of the proposed microinductive devices for very high sensitivity detection of biological molecules.
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Citations
Inductive Integrated Biosensor With Extended Operative Range for Detection of Magnetic Beads for Magnetic Immunoassay
Angela Beninato,Valentina Sinatra,Giuseppe Tosto,Maria Eloisa Castagna,Salvatore Petralia,Sabrina Conoci,Salvatore Baglio +6 more
TL;DR: An improved sensing architecture is proposed here, which allows one to expand the microsensor operative field toward very low bead concentrations, and confirms the suitability of the devices developed for magnetic immunoassay applications.
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Microinductive Signal Conditioning With Resonant Differential Filters: High-Sensitivity Biodetection Applications
Salvatore Baglio,Alejandro Pérez-Rodríguez,S. Martinez,Christophe Serre,Joan Ramon Morante,Jaume Esteve,Josep Montserrat +6 more
TL;DR: Measurements performed using micro-coils fabricated with relatively high series resistance and coupling parasitic effects have allowed detection of changes in the range of 2 nH, which are compatible with biodetection applications with estimated detection limits below the picomolarity range.
A novel silicon based mags-biosensor for nucleic acid detection by magnetoelectronic transduction
Maria Eloisa Castagna,Salvatore Petralia,Maria Grazia Amore,Emanuele Cappello,Angela Beninato,Valentina Sinatra,Salvatore Baglio,Sabrina Conoci +7 more
TL;DR: In this article, the authors developed a novel silicon biosensor based on magnetoelectronic transduction (MAGS) for nucleic acid detection, which is a planar device composed by a primary micro-coil, and two secondary coils which produce a differential voltage due to the induced magnetic field.
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Inductive microcoils for the fast and simple detection of bacterial presence
TL;DR: In this paper, microfabricated microcoils are alternatively exploited for the direct determination of bacteria presence in a completely reagentless format, based on the fact that the conductivity of the bacterial wall contributes to the overall medium conductivity, triggering a change of the magnetic field of the system and the microcoil inductance measured.
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Design and electrochemical preparation of inductive copper coils for magnetic particles detection
TL;DR: In this paper, a planar inductive planar coil was designed to detect magnetic particles in biodetection applications from the changes induced in coil inductance mounted in simple resonance differential filter circuit configurations.
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