Journal Article10.1177/26331055241246745
Sex Differences in Severity and Risk Factors for Ischemic Stroke in Patients With Hyperlipidemia
Emmanuel Imeh-Nathaniel,Samuel Imeh-Nathaniel,Adebobola Imeh‐Nathaniel,Oreoluwa O. Coker-Ayo,Nikhil Nitin Kulkarni,Thomas I. Nathaniel +5 more
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TL;DR: Sex differences in severity and risk factors for ischemic stroke in patients with hyperlipidemia. Increased ischemic stroke mortality risk score was associated with increased severity in both male and female AIS patients with hypertriglyceridemia.
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Abstract: Objective: This study aims to determine sex differences in poststroke hypertriglyceridemia (serum triglyceride levels ⩾ 200 mg/dl) and high stroke severity in ischemic stroke patients. Method: Our study analyzed data from 392 males and 373 females with hypertriglyceridemia. Stroke severity on admission was measured using the National Institute of Health Stroke Scale (NIHSS) with a value ⩽7 indicating a more favorable post-stroke prognosis while a score of >7 indicates poorer post-stroke outcomes. Logistic regression models adjusted for demographic and risk factors. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for each clinical risk factor were used to predict the increasing odds of an association of a specific clinical baseline risk factor with the male or female AIS with hypertriglyceridemia. Results: In the adjusted analysis, male patients with hypertriglyceridemia, diastolic blood pressure (OR = 1.100, 95% CI, 1.034-1.171, P = .002), and Ischemic stroke mortality (OR = 6.474, 95% CI, 3.262-12.847, P < .001) were significantly associated with increased stroke severity. In female patients with hypertriglyceridemia, age (OR = 0.920, 95% CI, 0.866-0.978, P = .008) was associated with reduced stroke severity, while ischemic stroke mortality score (OR = 37.477, 95% CI, 9.636-145.756, P < .001) was associated with increased stroke severity. Conclusion Increased ischemic stroke mortality risk score was associated with increased severity in both male and female AIS patients with hypertriglyceridemia. Our findings provide information about sex differences in specific risk factors that can be managed to improve the care of male and female ischemic stroke patients with hypertriglyceridemia.
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Citations
Trends and Disparities in Stroke Mortality Among Adults with Hyperlipidemia in the United States, 1999–2023
Muhammad Ahmed,Junaid Razzak,Khubaib Tariq Mansoor,Muhammad Abdullah Naveed,Ahila Ali,Muhammad Shaheer Bin Faheem,Sumaya Samadi,Himaja Dutt Chigurupati,SIVARAM NEPPALA,Muhammad Ahmed,Junaid Razzak,Khubaib Tariq Mansoor,Muhammad Abdullah Naveed,Ahila Ali,Muhammad Shaheer Bin Faheem,Sumaya Samadi,Himaja Dutt Chigurupati,SIVARAM NEPPALA +17 more
Abstract: This analysis reveals significant demographic and racial disparities in Stroke mortality among U.S. adults with Hyperlipidemia, which highlights the urgent need for targeted, equity-focused interventions to address these disparities.
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