Journal Article10.1056/NEJMRA1208623
Severe sepsis and septic shock
Derek C. Angus,Tom van der Poll +1 more
TL;DR: A review of the basis, diagnosis, and current treatment of Sepsis in patients with this disorder is examined.
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Abstract: Morbidity and mortality from sepsis remains unacceptably high. Large variability in clinical practice, plus the increasing awareness that certain processes of care associated with improved critical...
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Citations
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more
TL;DR: The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock.
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Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations.
Carolin Fleischmann,André Scherag,Neill K. J. Adhikari,Christiane S. Hartog,Thomas Tsaganos,Peter Schlattmann,Derek C. Angus,Konrad Reinhart +7 more
TL;DR: In this paper, the authors systematically searched 15 citation databases for population-level estimates of sepsis incidence rates and fatality in adult populations using consensus criteria and published in the last 36 years.
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A Randomized Trial of Protocol-Based Care for Early Septic Shock
Donald M. Yealy,John A. Kellum,David T. Huang,Lisa A. Weissfeld,Francis Pike,Thomas E. Terndrup,Peter C. Hou,Frank LoVecchio,Michael R. Fil,Nathan I. Shapiro,Beth,Derek C. Angus +11 more
TL;DR: In a multicenter trial conducted in the tertiary care setting, protocol-based resuscitation of patients in whom septic shock was diagnosed in the emergency department did not improve outcomes.
Cytokines in Inflammatory Disease.
TL;DR: This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines, focusing on the correlations and role of these inflammatory mediators in the genesis of inflammatory impacts.
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Epidemiology of severe sepsis.
TL;DR: People of older age, male gender, black race, and preexisting chronic health conditions are particularly prone to develop severe sepsis; hence prevention strategies should be targeted at these vulnerable populations in future studies.
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