Journal Article10.1016/J.ATHEROSCLEROSIS.2011.02.022
Serum secreted phospholipase A2 is associated with abdominal aortic aneurysm presence but not progression.
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TL;DR: Serum sPLA(2) activity is elevated in men with small AAAs but is not associated with AAA progression, independent of other risk factors.
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About: This article is published in Atherosclerosis. The article was published on 01 Jun 2011.
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Citations
Emerging roles of secreted phospholipase A(2) enzymes: an update.
Makoto Murakami,Gérard Lambeau +1 more
TL;DR: It is now obvious that individual sPLA(2)s are involved in diverse biological events through lipid mediator-dependent and -independent processes, act redundantly or non-redundantly in the context of physiology and pathophysiology, and may represent potential drug targets or novel bioactive molecules in certain situations.
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Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice.
TL;DR: It is indicated that GV sPLA(2) modulates pathological responses to Ang II, with different outcomes for AAA and cardiac fibrosis.
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Metabolomic Profile of Abdominal Aortic Aneurysm.
J. Lieberg,Anders Wanhainen,Aigar Ottas,Mare Vähi,Mihkel Zilmer,Ursel Soomets,Martin Björck,Jaak Kals +7 more
TL;DR: In this paper, the authors compared 183 low molecular weight metabolites in abdominal aortic aneurysm (AAA) patients and aorta-healthy controls, and found no associations with AAA growth rate.
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Metabolomic Profiling of Angiotensin-II-Induced Abdominal Aortic Aneurysm in Ldlr−/− Mice Points to Alteration of Nitric Oxide, Lipid, and Energy Metabolisms
Juan Manuel Chao de la Barca,A. Katz Richard,Pauline Robert,Maroua Eid,Olivier Fouquet,Lydie Tessier,Céline Wetterwald,Justine Faure,Céline Fassot,Daniel Henrion,Pascal Reynier,Laurent Loufrani +11 more
TL;DR: It is revealed that experimental induction of aortic aneurysms causes a profound alteration in the metabolic profile in aortas and blood, mainly centered on an alteration of NO, lipid, and energetic metabolisms.
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References
Atherosclerosis and abdominal aortic aneurysm: cause, response, or common risk factors?
Jonathan Golledge,Paul Norman +1 more
TL;DR: On the basis of the new insights from rodent models, a number of novel strategies are being investigated as potential treatments for small AAA, and the importance of inflammatory pathways, matrix degradation, thrombosis, hemodynamic forces, and a host of associated signaling molecules in AAA pathogenesis is suggested.
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Lipoprotein-Associated and Secreted Phospholipases A2 in Cardiovascular Disease
TL;DR: The PLA2 lipid products lead to the generation of a variety of downstream signaling molecules, including prostaglandins, leukotrienes, lysophospholipids, platelet-activating factor (PAF), and oxidized lipids, that induce a multitude of biological actions in virtually all tissues, including the cardiovascular system.
186
Oxidation-specific biomarkers, lipoprotein(a), and risk of fatal and nonfatal coronary events.
Sotirios Tsimikas,Ziad Mallat,Philippa J. Talmud,John J.P. Kastelein,Nicholas J. Wareham,Manjinder S. Sandhu,Elizabeth R. Miller,Joelle Benessiano,Alain Tedgui,Joseph L. Witztum,Kay-Tee Khaw,S. Matthijs Boekholdt +11 more
TL;DR: The highest tertiles of oxidized phospholipids on apolipoprotein B-100 particles and Lp(a) were associated with a significantly higher risk of CAD events than the lowest tertiles, and c-index values progressively increased when oxidative biomarkers were added to the model.
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A comparative study of the prevalence of abdominal aortic aneurysms in the United Kingdom, Denmark, and Australia:
TL;DR: In this paper, the authors compared attendance and prevalence of abdominal aortic aneurysm (AAA) in population-based randomised trials of sonographic screening in the United Kingdom, Western Australia, and Denmark.
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Secretory phospholipase A2 group V: lesion distribution, activation by arterial proteoglycans, and induction in aorta by a Western diet.
Birgitta Rosengren,Helena Peilot,Mia Umaerus,Ann-Cathrine Jönsson-Rylander,Lillemor Mattsson-Hultén,Carina Hallberg,Philippe Cronet,Mariam Rodriguez-Lee,Eva Hurt-Camejo +8 more
TL;DR: These results indicate that these phospholipases could have different roles in atherosclerosis and are indicated to be associated with smooth muscle cells and also surrounding foam cells in lipid core areas.
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