Journal Article10.1097/MPH.0B013E3181B38B4E
Sequential Transplants for Respective Relapse of Hodgkin Disease and Hemophagocytic Lymphohistiocytosis: A Treatment Dilemma
Yu Hsiang Chang,Yu Hsiang Chang,Yu Hsiang Chang,Pei Jung Lu,Meng-Yao Lu,Jyh Seng Wang,Chun Liang Tung,Chen Fu Shaw +7 more
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TL;DR: The recurrence of HLH with a high Epstein-Barr virus load but without relapse of HD in the patient suggests that Epstein- Barr virus may have a major pathogenetic role in the specific disorder HLH-HD.
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Abstract: The association of hemophagocytic lymphohistiocytosis (HLH) with Hodgkin disease (HD) seems to be uncommon. A 9-year-old boy, diagnosed with HD-HLH, received chemotherapy and remained in complete remission for 21 months. Then the patient received the first autologous transplant and unfortunately die
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Citations
Successful treatment of recurrent malignancy-associated hemophagocytic lymphohistiocytosis with a modified HLH-94 immunochemotherapy and allogeneic stem cell transplantation
TL;DR: The case of a young woman with recurrent ALK1-positive anaplastic large T-cell lymphoma and M-HLH successfully treated with a modified HLH-94 protocol, allogeneic stem cell transplantation (alloSCT) and donor lymphocyte infusion (DLI), and it is proposed that alloSCT should be considered in eligible individuals.
Autoimmune-Associated Hemophagocytic Syndrome/Macrophage Activation Syndrome
Maciej Machaczka,Wojciech Sydor,Malgorzata Rucinska,Marta Szostek,Jacek Musiał +4 more
- 14 Nov 2011
TL;DR: Hemophagocytic syndrome (HPS) encompasses an infrequent group of non-malignant, yet potentially life-threatening disorders caused by massive cytokine release from activated lymphocytes and macrophages.
Hemophagocytic Syndrome Associated with Hodgkin's Lymphoma First Presenting as Fever and Pancytopenia.
TL;DR: HPS associated with HL is a very rare and lethal disease, with mortality rates of about 15% to 60%.
Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis—a dangerous disease
TL;DR: HL patients found positive for EBV (plasma/PBMCs EBV-DNA(+)/EBER(+)) may be more likely to develop HLH-HL, and it may be beneficial to target HLH during the acute phase of HLH, followed by treating HL once the HLH condition has stabilized.
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Specyfika występowania limfohistiocytozy hemofagocytarnej w okresie wieku dorosłego
TL;DR: Basic knowledge of this entity and its diagnostic criteria should be familiar to all physicians as it is difficult, long-lasting and often associated with a high morbidity.
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References
HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.
Jan-Inge Henter,AnnaCarin Horne,Maurizio Aricò,R. Maarten Egeler,Alexandra H. Filipovich,Shinsaku Imashuku,Stephan Ladisch,Kenneth L. McClain,David Webb,Jacek Winiarski,Gritta Janka +10 more
TL;DR: HLH‐2004 chemo‐immunotherapy includes etoposide, dexamethasone, cyclosporine A upfront and, in selected patients, intrathecal therapy with methotrexate and corticosteroids, and subsequent hematopoietic stem cell transplantation is recommended for patients with familial disease or molecular diagnosis, and patients with severe and persistent, or reactivated, disease.
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Familial and acquired hemophagocytic lymphohistiocytosis
TL;DR: In conclusion, awareness of the clinical symptoms and of the diagnostic criteria of HLH is crucial in order not to overlook HLH and to start life-saving therapy in time.
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Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease.
TL;DR: The findings suggest that EBV is associated with more cases of HD than was previously recognised, that in positive cases RS cells express a latent infection protein phenotype which differs from that of other EBV-associated lymphomas, and that LMP expression is related to histologically aggressive subtypes of HD.
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Guidelines for interpreting EBER in situ hybridization and LMP1 immunohistochemical tests for detecting Epstein-Barr virus in Hodgkin lymphoma.
Margaret L. Gulley,Sally L. Glaser,Fiona E. Craig,Michael J. Borowitz,Risa B. Mann,Sarah J. Shema,Richard F. Ambinder +6 more
TL;DR: Four hematopathologists independently interpreted EBV-encoded RNA (EBER) and latent membrane protein 1 (LMP1) histochemical stains from 40 cases of Hodgkin lymphoma and then reviewed the stains as a group to resolve discrepancies and to develop interpretation guidelines.
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Use of rituximab in conjunction with immunosuppressive chemotherapy as a novel therapy for Epstein Barr virus-associated hemophagocytic lymphohistiocytosis.
TL;DR: A patient with severe EBV-hemophagocytic lymphohistiocytosis is treated using a combination of rituximab and chemotherapy and remains free of disease 8 months after completing treatment.
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