Journal Article10.1097/00000542-200106000-00027
Sensory processing in the deep spinal dorsal horn of neurokinin-1 receptor knockout mice.
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TL;DR: It is indicated that neurokinin-1 receptors do not play a significant role in the responses of nociceptive neurons in the deep spinal dorsal horn to acute noxious mechanical, thermal, electrical, or chemical stimuli, and central hyperexcitability is observed in these neurons with repeated C-fiber inputs.
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Abstract: Background The neurokinin-1 receptor and its primary ligand, substance P, are widely recognized as contributing to the spinal processing of nociceptive stimuli, yet the specific function of the neurokinin-1 receptor remains unclear. Methods To better clarify these functions, the authors examined the neurophysiologic responses of L4–L5 neurons in the deep dorsal horn to acute mechanical, thermal, and electrical stimuli in knockout and wild-type mice. In addition, the capacity of knockout and wild-type mice to show wind-up to repeated C-fiber stimuli and to show sensitization after cutaneous mustard oil was assessed. Results A total of 68 nociceptive neurons (35 in knockout, 33 in wild type) in laminae III–V were studied. No differences in the acute responses of neurons in knockout and wild-type mice to graded mechanical, thermal, or electrical stimuli or in the acute responses to mustard oil were observed. However, wind-up to repeated electrical stimulation at C-fiber intensity was significantly attenuated in the knockout mice compared with wild type controls. In addition, mustard oil–induced mechanical hypersensitivity was significantly reduced in the knockout mice. Conclusions These results indicate that neurokinin-1 receptors do not play a significant role in the responses of nociceptive neurons in the deep spinal dorsal horn to acute noxious mechanical, thermal, electrical, or chemical stimuli. On the other hand, neurokinin-1 receptors are critical for the central hyperexcitability that is observed in these neurons with repeated C-fiber inputs and to the central sensitization induced by topical mustard oil application.
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Spinal neurons that possess the substance P receptor are required for the development of central sensitization.
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Long-term potentiation in spinothalamic neurons
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