Sense and sensibility: nutritional response and signal integration in yeast.

TL;DR: Recent advances and new insights about MAPK-based signaling that have been made through studies in yeast are highlighted, which provide lessons directly applicable to, and that enhance the understanding of,MAPK-mediated signaling in mammalian cells.

TL;DR: It is proposed that Arabidopsis NRT2.1 acts either as a nitrate sensor or signal transducer to coordinate the development of the root system with nutritional cues and that this role is independent of nitrate uptake.

TL;DR: The network analysis of the systematic dataset of CN treatments indicates that CN sensing is a mechanism that coordinates the global and coordinated regulation of specific sets of molecular machines in the plant cell.

TL;DR: It is shown that Tor1 is dynamically distributed in the cytoplasm and nucleus in yeast, indicating that the spatial regulation of TOR complex 1 (TORC1) might be involved in differential control of its target genes.

TL;DR: This work determines how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells, and identifies network motifs, the simplest units of network architecture, and demonstrates that an automated process can use motifs to assemble a transcriptional regulatory network structure.

TL;DR: Two functionally distinct TOR complexes account for the diversity, specificity, and selective rapamycin inhibition of TOR signaling.

TL;DR: Mitochondrial retrograde signaling is a pathway of communication from mitochondria to the nucleus that influences many cellular and organismal activities under both normal and pathophysiological conditions.

TL;DR: Genetic analysis revealed a complex network of newly found factors that govern critical cell size at Start, the most potent of which were Sfp1, Sch9, Cdh1, Prs3, and Whi5.