Journal Article10.1149/10701.16673ecst
Self-Reporting Molecularly Imprinted Polymer-Based Electrochemical Sensors for Structurally Similar Analytes
Vignesh Magudeeswaran,Jayasudha Velayutham,Sriraja Subhasri Paramasivam,Gopi Karuppaiah,Siva Ananth Mariappan,Pandiaraj Manickam +5 more
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TL;DR: In this article , a self-reporting molecular imprinted polymers (MIPs) with inherent redox activity was developed for reagent-free electrochemical detection of steroid hormone biomarker cortisol, where Ferrocenylmethyl methacrylate and acrylic acid were used as redox and functional monomers.
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Abstract: Molecularly imprinted polymers (MIPs) having inherent redox activity is developed for reagent-free electrochemical detection of steroid hormone biomarker cortisol. Ferrocenylmethyl methacrylate and acrylic acid were used as redox and functional monomers, respectively. Free radical initiated co-polymerization process was performed in the presence of cortisol as a template to create electroactive MIPs. The copolymerized ferrocenylmethyl methacrylate network provided the redox-active and self-reporting electrochemical platform for detecting redox-inactive biomarkers without using any additional reagents. Cortisol is chosen as the model analyte to evaluate the performance of the self-reporting molecular recognition property. The self-reporting MIPs allowed the quantitative detection of cortisol (as low as 0.5 ng) in the presence of other structurally similar steroid hormones.
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Citations
Electrochemical sensors for cortisol detection: Principles, designs, fabrication, and characterisation.
TL;DR: Despite significant advancements, the development of electrochemical cortisol sensors faces challenges such as biofouling, sample preparation, sensitivity, flexibility, stability, and recognition layer performance, and the need to develop more sensitive electrodes and materials is emphasized.
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Introducing Nanoscale Electrochemistry in Small-Molecule Detection for Tackling Existing Limitations of Affinity-Based Label-Free Biosensing Applications.
Don Hui Lee,Won-Yong Lee,Jayoung Kim +2 more
TL;DR: Researchers introduce nanoscale electrochemistry for small-molecule detection, overcoming limitations of affinity-based biosensing by developing a nanoscale molecularly imprinted composite polymer (MICP) sensor with high sensitivity and reversible detection capability.
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Emerging trends in functional molecularly imprinted polymers for electrochemical detection of biomarkers
Sanjida Yeasmin,Li-Jing Cheng +1 more
TL;DR: Emerging trends in functional molecularly imprinted polymers for electrochemical detection of biomarkers focus on redox-active MIP sensors for direct and label-free electrochemical detection. These sensors offer high stability, cost-effectiveness, high selectivity, and sensitivity. Recent progress in wearable and POC redox-active MIP sensors is highlighted.
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