Selenium and tellurium in the development of novel small molecules and nanoparticles as cancer multidrug resistance reversal agents.
Enrique Domínguez-Álvarez,Bálint Rácz,Małgorzata Anna Marć,Muhammad Jawad Nasim,Nikoletta Szemerédi,Jitka Viktorova,Claus Jacob,Gabriella Spengler +7 more
58
TL;DR: In this paper , an overview of the biological activities of seleno-and telluro-containing compounds including chemopreventive activity, antioxidant or pro-oxidant activity, modulation of the inflammatory processes, induction of apoptosis and modulation of autophagy, inhibition of multidrug efflux pumps such as P-gp, selective targeting of tumors and enhancement of the cytotoxic activity of chemotherapeutic drugs, as well as overcoming tumor drug resistance.
read more
About: This article is published in Drug Resistance Updates. The article was published on 02 May 2022. and is currently open access. The article focuses on the topics: Medicine & Selenium.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
ATP-binding cassette efflux transporters and MDR in cancer.
Manasi S. Pote,Rajesh N. Gacche +1 more
TL;DR: In this article , a review of the structure, function, and regulatory mechanisms of major MDR related ABC transporters such as P-glycoprotein, MRP1, BCRP and effect of modulators on their functions is presented.
71
Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine
Marjorie C Zambonino,Ernesto Mateo Quizhpe,Lynda Mouheb,Atta ur Rahman,Spiros N. Agathos,Si Amar Dahoumane +5 more
TL;DR: In this article , a comprehensive review of the potential of biogenic selenium nanoparticles in the biomedical field is presented, which highlights the current, yet expanding, possibilities offered by biogenic SeNPs in biomedical field and the promise of future developments.
61
Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics
Harshita Tiwari,Nilesh K. Rai,Priyamvada Gupta,A.R. Verma,Prafull Salvi,Santosh Kumar Singh,Vibhav Gautam +6 more
TL;DR: A wide range of nanocarriers, such as dendrimers, micelles, PEGylated liposomes, and polymeric nanoparticles are used to facilitate the efficient transport of anti-cancer drugs at the target tumor site as discussed by the authors .
Package delivered: folate receptor-mediated transporters in cancer therapy and diagnosis
Mohsen Ahmadi,Christoph A. Ritter,Thomas von Woedtke,Sander Bekeschus,Kristian Wende +4 more
TL;DR: Recent advances spanning 2017 to 2023 in conjugated nanocarriers and small molecule drug conjugates were considered, evaluating the chemical and biological aspects in order to improve accessibility to the field and to bridge chemical and biomedical points of view ultimately guiding future research in FR-targeted cancer therapy and diagnosis.
20
Precise-engineering of Se/Te Nanochaperone for Reinvigorating Cancer Radio-immunotherapy.
TL;DR: In this paper , a universal method for synthesizing chalcogen-based TeSe nanoheterojunctions with rod-, spindle- or dumbbell-like morphologies by engineering the surfactant and added selenite.
19
References
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
TL;DR: In addition to their role in extracellular matrix turnover and cancer cell migration, MMPs regulate signaling pathways that control cell growth, inflammation, or angiogenesis and may even work in a nonproteolytic manner.
4.9K
The importance of selenium to human health
TL;DR: Selenium is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS.
4K
Tumour stem cells and drug resistance
TL;DR: Gaining a better insight into the mechanisms of stem-cell resistance to chemotherapy might lead to new therapeutic targets and better anticancer strategies.
Reactive oxygen species in cancer
Geou Yarh Liou,Peter Storz +1 more
TL;DR: The generation of ROS within tumour cells, their detoxification, their cellular effects, as well as the major signalling cascades they utilize are discussed, but also an outlook on their modulation in therapeutics is provided.
Selenium and human health
TL;DR: The crucial factor that needs to be emphasised with regard to the health effects of selenium is the inextricable U-shaped link with status; whereas additional seenium intake may benefit people with low status, those with adequate-to-high status might be affected adversely and should not take selenum supplements.
2.9K