Secretion without Golgi
Igor Prudovsky,Francesca Tarantini,Matteo Landriscina,David J. Neivandt,Raffaella Soldi,Aleksandr Kirov,Deena Small,Karuppanan Muthusamy Kathir,Dakshinamurthy Rajalingam,Thallapuranam Krishnaswamy Suresh Kumar +9 more
TL;DR: Non‐classical release of FGF1 and IL1α presents a promising target for treatment of cardiovascular, oncologic, and inflammatory disorders.
read more
Abstract: A growing number of proteins devoid of signal peptides have been demonstrated to be released through the non-classical pathways independent of endoplasmic reticulum and Golgi. Among them are two potent proangiogenic cytokines FGF1 and IL1α. Stress-induced transmembrane translocation of these proteins requires the assembly of copper-dependent multiprotein release complexes. It involves the interaction of exported proteins with the acidic phospholipids of the inner leaflet of the cell membrane and membrane destabilization. Not only stress, but also thrombin treatment and inhibition of Notch signaling stimulate the export of FGF1. Non-classical release of FGF1 and IL1α presents a promising target for treatment of cardiovascular, oncologic, and inflammatory disorders.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer
TL;DR: S 100A8/S100A9 is not only involved in promoting the inflammatory response in infections but was also identified as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread.
845
Mechanisms of regulated unconventional protein secretion
TL;DR: The mechanisms and molecular components of unconventional protein secretion are beginning to emerge, including a role for caspase 1 and for the peripheral Golgi protein GRASP, which could function as a plasma membrane tether for membrane compartments during specific stages of development.
696
Interleukin-33 – cytokine of dual function or novel alarmin?
Guttorm Haraldsen,Johanna Balogh,Johanna Balogh,Jürgen Pollheimer,Jürgen Pollheimer,Jon Sponheim,Axel M. Küchler,Axel M. Küchler +7 more
TL;DR: Current knowledge of cytokines, including the novel interleukin (IL)-1 family member IL-33, is reviewed, considering to what extent IL- 33 can be seen as a novel member of the alarmin family.
324
Galectins in innate immunity: dual functions of host soluble β‐galactoside‐binding lectins as damage‐associated molecular patterns (DAMPs) and as receptors for pathogen‐associated molecular patterns (PAMPs)
TL;DR: The glycocalyx is a glycan layer found on the surfaces of host cells as well as microorganisms and enveloped virus, which contains various structurally different glycans, which provide cell‐ or microorganism‐specific ‘glycoinformation’ and is decoded by host glycan‐binding proteins, lectins.
294
Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases
TL;DR: Intracellular substrate proteolysis by MMPs is involved in innate immune defense and apoptosis, and affects oncogenesis and pathology of cardiac, neurological, protein conformational and autoimmune diseases, including ischemia-reperfusion injury, cardiomyopathy, Parkinson’s disease, cataract, multiple sclerosis and systemic lupus erythematosus.
290
References
Biologic basis for interleukin-1 in disease
TL;DR: This is a lengthy review, with 586 citations chosen to illustrate specific areas of interest rather than a compendium of references, which summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease.
4.6K
Fibroblast growth factors
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: A subset of the FGF family, expressed in adult tissue, is important for neuronal signal transduction in the central and peripheral nervous systems.
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
Tiziana Bonaldi,Fabio Talamo,Paola Scaffidi,Denise Ferrera,Annalisa Porto,Angela Bachi,Anna Rubartelli,Alessandra Agresti,Marco Bianchi +8 more
TL;DR: It is shown here that in all cells HMGB1 shuttles actively between the nucleus and cytoplasm, and secreted when monocytic cells receive an appropriate second signal.
Molten globule and protein folding.
TL;DR: It is predicted and confirmed experimentally that the molten globule state can exist in a living cell and plays an important role in a number of physiological processes.
1.2K
Fibroblast growth factors
TL;DR: FGF receptors 1–3 are subject to alternative splicing which alters their specificity for the different ligands, and it is clear that ligand–receptor specificities can be modulated according to which GAGs present the ligands.
1.1K