Screening for new pharmaceutical solid forms using mechanochemistry: A practical guide.

TL;DR: For a review of the state-of-the-art in mechanochemistry, see, e.g., this article, the review presented in this paper. But, there still remains some mystique guarding the "rules" of mechanochemistry.

TL;DR: In this article, the authors present a series of examples that will clearly illustrate how mechanochemistry can significantly contribute to the fulfillment of Green Chemistry in a more holistic manner, and demonstrate that mechanochemistry satisfies more than one of the principles of green chemistry.

TL;DR: This Account describes efforts at focusing down into mechanical properties of organic molecular crystals from the viewpoint of crystal engineering, which is the synthesis and design of functional molecular solids and presents examples where complex properties may be deliberately turned on or off in organic crystals.

TL;DR: Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes, supramolecular aspects and characterization methods.

TL;DR: The aim of this review article is to provide a comprehensive overview of advances achieved in the field of atomistic processes, phase transformations, simple and multicomponent nanosystems and peculiarities of mechanochemistry.

TL;DR: Although the polymorph (form II) corresponding to the “cis” conformation is a more stable packing arrangement, nucleation, even in the presence of form II seeds, is energetically unfavored except in highly supersaturated solutions.

TL;DR: Seven recent case studies that illustrate how pharmaceutical cocrystals can improve physicochemical properties and clinical performance of drug substances, including a recently approved drug product based upon an ICC, are presented.