Sarcopenia: Aging-Related Loss of Muscle Mass and Function.

TL;DR: Early pilot trials of senolytics suggest they decrease senescent cells, reduce inflammation and alleviate frailty in humans, opening a new route for treating age‐related dysfunction and diseases.

TL;DR: It is demonstrated that rapamycin disrupted a second mTOR complex, m TORC2, in vivo and that mTORC2 was required for the insulin-mediated suppression of hepatic gluconeogenesis and was sufficient to extend life span independently from changes in glucose homeostasis.

TL;DR: Parl-associated rhomboid-like (PARL-like) as mentioned in this paper is an inner mitochondrial membrane rhomboids of unknown function, whose yeast ortholog is involved in mitochondrial fusion.

TL;DR: The rationale for senescent cells as a therapeutic target for disorders across the lifespan is outlined and the most promising strategies-including recent and ongoing clinical trials-for translating small-molecule senolytics and other senescence-targeting interventions into clinical use are discussed.

TL;DR: The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.

TL;DR: PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation of the nuclear respiratory factors (NRFs).

TL;DR: Results suggest that GDF-8 functions specifically as a negative regulator of skeletal muscle growth, which is significantly larger than wild-type animals and show a large and widespread increase in skeletal muscle mass.

TL;DR: RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in P GC-1alpha acetylation and an increase in PGC-1 alpha activity.