Open AccessJournal Article
Sapylin immunotherapy in oral squamous cancer
1
TL;DR: Sapylin that may be a useful to biological response modifier (BRM) agent for oral squamous cancer without treatment that was injected into normal submucosa or sub-skin around the tumor.
read more
Abstract: A streptococcal preparation, Sapylin, was employed for 27 cases of oral squamous cancer without treatment that was injected into normal submucosa or sub-skin around the tumor. The recent clinical efficacy is as follows: 3 cases specially effective, 10 cases marked effective, 6 cases effective and 8 cases not effective. Effective percent 70%. A delayed SK-SD skin reaction were found to enhance, but NK activity and T-Rosette were not. A middle grade fever was present as a side effect of this preparation. The result suggested Sapylin that may be a useful to biological response modifier (BRM) agent for oral squamous cancer.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Sapylin (OK-432) alters inflammation and angiogenesis in vivo and vitro.
TL;DR: Sapylin could stimulate the body to secrete a variety of cytokines to promote wound healing by promoting endothelial cell proliferation and migration, angiogenesis and by increasing fibroblast migration and collagen deposition.
4