Journal Article10.1097/MED.0000000000000328
Salivary cortisol and cortisone in the clinical setting.
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TL;DR: Salivary cortisol and cortisone can be used to assess cortisol excess, deficiency and hydrocortisone replacement, with salivary cortis one having the advantage of detection when serum cortisol levels are low and there is no interference from oral hydroc Cortisone.
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Abstract: Purpose of reviewA resurgence of interest in salivary biomarkers has generated evidence for their value in assessing adrenal function. The advantages of salivary measurements include only free hormone is detected, samples can be collected during normal daily routines and stress-induced cortisol rele
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Citations
Liquid chromatography–tandem mass spectrometry for clinical diagnostics
TL;DR: Thomas et al. as mentioned in this paper discuss experimental considerations and quality management for implementing clinical tandem mass spectrometry in the clinic with an overview of some key applications, and provide an outlook of where there are emerging clinical applications for this technology.
•Journal Article
Cortisol levels and measures of body composition in middle-aged and older men. Commentary
Rebecca M. Reynolds,Brian R. Walker,Thomas G. Travison,Amy B. O’Donnell,Andre B. Araujo,Alvin M. Matsumoto,John B. McKinlay +6 more
TL;DR: In this article, a cross-sectional and longitudinal association between body composition and serum cortisol concentrations in a randomly chosen group of 999 community-dwelling men, aged 40-79 years, was found.
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Salivary cortisone, as a biomarker for psychosocial stress, is associated with state anxiety and heart rate.
Yoon Ju Bae,Janis Reinelt,Jeffrey Netto,Marie Uhlig,Anja Willenberg,Uta Ceglarek,Arno Villringer,Joachim Thiery,Michael Gaebler,Juergen Kratzsch +9 more
TL;DR: Salivary cortisone was found to be a stress biomarker with high discriminatory power and significant correlations with subjective and autonomic stress measures and can inform future stress studies of sampling time for different laboratory parameters.
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Use of late-night salivary cortisol to monitor response to medical treatment in Cushing’s disease
John Newell-Price,Rosario Pivonello,Antoine Tabarin,Maria Fleseriu,Przemysław Witek,Mônica R. Gadelha,Stephan Petersenn,Libuse Tauchmanova,Shoba Ravichandran,Pritam Gupta,André Lacroix,Beverly M. K. Biller +11 more
TL;DR: In this article, the late-night salivary cortisol (LNSC) was calculated from two samples, collected on the same days as the first two of three 24-h urine samples (used to calculate mean UFC [mUFC]). Clinical signs of hypercortisolism were evaluated over time.
Towards the development of reagent-free and reusable electrochemical aptamer-based cortisol sensor.
Gopi Karuppaiah,Jayasudha Velayutham,Shekhar Hansda,Nagesh Narayana,Shekhar Bhansali,Pandiaraj Manickam +5 more
TL;DR: In this paper , a reagentless aptamer-based biosensing platform that allows a continuous and real-time cortisol measurement is developed in which the aptamer is conjugated with methylene blue, which acts as a redox reporter to probe the cortisol binding quantitatively on the sensor surface.
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References
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TL;DR: Developing clinical practice guidelines for the diagnosis of Cushing's syndrome in patients with multiple and progressive features compatible with the syndrome, particularly those with a high discriminatory value, and patients with adrenal incidentaloma is recommended.
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Measurements of Serum Free Cortisol in Critically Ill Patients
TL;DR: In this study, nearly 40 percent of critically ill patients with hypoproteinemia had subnormal serum total cortisol concentrations, even though their adrenal function was normal, which may help prevent the unnecessary use of glucocorticoid therapy.
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Tissue-specific dysregulation of cortisol metabolism in human obesity.
Eva Rask,Tommy Olsson,Stefan Söderberg,Ruth Andrew,Dawn E. W. Livingstone,Owe Johnson,Brian R. Walker +6 more
TL;DR: In obesity, reactivation of cortisone to cortisol by 11beta-HSD1 in liver is impaired, so that plasma cortisol levels tend to fall, and there may be a compensatory increase in cortisol secretion mediated by a normally functioning hypothalamic-pituitary-adrenal axis.
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Health Status of Adults with Congenital Adrenal Hyperplasia: A Cohort Study of 203 Patients
Wiebke Arlt,Debbie S. Willis,Sarah H. Wild,Nils Krone,Emma J. Doherty,Stefanie Hahner,Thang S. Han,Paul V. Carroll,G. S. Conway,D. Aled Rees,Roland H Stimson,Brian R. Walker,John M. C. Connell,Richard J. Ross +13 more
TL;DR: In the patients studied, glucocorticoid replacement was generally nonphysiological, and androgen levels were poorly controlled, associated with an adverse metabolic profile and impaired fertility and quality of life.
Late-night salivary cortisol as a screening test for Cushing's syndrome.
TL;DR: Evaluated late-night salivary cortisol measurements may simplify the evaluation of suspected intermittent hypercortisolism, and they may facilitate the screening of large high-risk populations (e.g. patients with diabetes mellitus).