Journal Article10.1016/J.BMCL.2018.11.008
Rotenoisin A is a novel anti-adipogenic compound.
Hang-Hee Cho,Hyeon Soo Park,Sun-Hee Jang,Chung-Kil Won,Hong Duck Kim,Tae Hoon Kim,Jae-Hyeon Cho +6 more
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TL;DR: The results demonstrated that the anti-adipogenesis mechanism involves the down-regulation of critical adipogenic transcription factors, including C/EBPβ, C/ EBPα, and PPARγ, through activation of the AMPK signaling pathway by rotenoisin A.
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About: This article is published in Bioorganic & Medicinal Chemistry Letters. The article was published on 01 Jan 2019. The article focuses on the topics: AMPK & Adipogenesis.
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Citations
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. An update from 2017 to early 2022.
TL;DR: A review of small molecule inhibitors of FABP4 can be found in this article , where the authors update the recently reported (2017 to early 2022) molecules as adipocyte fatty acid binding protein 4 inhibitors.
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HM-chromanone inhibits adipogenesis by regulating adipogenic transcription factors and AMPK in 3T3-L1 adipocytes
TL;DR: HM-chromanone may be an effective anti-adipogenesis agent that functions via the suppression of adipogenic transcription factors and the activation of AMPK.
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Novel Dihydrocoumarins Induced by Radiolysis as Potent Tyrosinase Inhibitors
Gyeong Han Jeong,Manisha Yadav,Seung Sik Lee,Byung Yeoup Chung,Jae-Hyeon Cho,In-Chul Lee,Hyoung-Woo Bai,Tae Hoon Kim +7 more
TL;DR: The unusual bisdihydrocoumarin 4 exhibited improved tyrosinase inhibitory capacity toward mushroom tyrosinase with IC50 values of 19.8 ± 0.5 μM as compared to the original 4-methylumbelliferone.
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Inhibitory Effects of Thermolysis Transformation Products of Rotenone on Nitric Oxide Production
TL;DR: In this article , the authors showed that the thermal transformation of rotenone can improve the functionality of anti-inflammatory agents, such as tubaic acid and isoflavonoid derivatives.
References
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C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.
Evan D. Rosen,Chung-Hsin Hsu,Xinzhong Wang,Shuichi Sakai,Mason W. Freeman,Frank J. Gonzalez,Bruce M. Spiegelman +6 more
TL;DR: This work has created an immortalized line of fibroblasts lacking PPARgamma, which is used to show that C/EBPalpha has no ability to promote adipogenesis in the absence of PPARGamma, and indicates that C- EBPalpha and PPAR Gamble participate in a single pathway of fat cell development.
The AMP‐Activated Protein Kinase
D. Grahame Hardie,David Carling +1 more
TL;DR: The central hypothesis is that the AMP-activated protein kinase cascade appears to be an ancient system which evolved to protect cells against the effects of nutritional or environmental stress, and protects the cell by switching off ATP-consuming pathways and switching on alternative pathways for ATP generation.
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Molecular Regulation of Adipogenesis
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