Role of Transient Receptor Potential Vanilloid 4 in Vascular Function
Liangliang Liu,Mengting Guo,Xiaowang Lv,Zhiwei Wang,Jigang Yang,Yanting Li,Fan Yu,Xin Wen,Lei Feng,Tingting Zhou +9 more
- 26 Apr 2021
- Vol. 8, pp 677661-677661
TL;DR: Transient receptor potential vanilloid 4 (TRPV4) channels are widely expressed in systemic tissues and can be activated by many stimuli as mentioned in this paper, which can play an important role in the vasculature and is implicated in the regulation of cardiovascular homeostasis processes such as blood pressure, vascular remodeling, and pulmonary hypertension and edema.
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Abstract: Transient receptor potential vanilloid 4 (TRPV4) channels are widely expressed in systemic tissues and can be activated by many stimuli. TRPV4, a Ca2+-permeable cation channel, plays an important role in the vasculature and is implicated in the regulation of cardiovascular homeostasis processes such as blood pressure, vascular remodeling, and pulmonary hypertension and edema. Within the vasculature, TRPV4 channels are expressed in smooth muscle cells, endothelial cells, and perivascular nerves. The activation of endothelial TRPV4 contributes to vasodilation involving nitric oxide, prostacyclin, and endothelial-derived hyperpolarizing factor pathways. TRPV4 activation also can directly cause vascular smooth muscle cell hyperpolarization and vasodilation. In addition, TRPV4 activation can evoke constriction in some specific vascular beds or under some pathological conditions. TRPV4 participates in the control of vascular permeability and vascular damage, particularly in the lung capillary endothelial barrier and lung injury. It also participates in vascular remodeling regulation mainly by controlling vasculogenesis and arteriogenesis. This review examines the role of TRPV4 in vascular function, particularly in vascular dilation and constriction, vascular permeability, vascular remodeling, and vascular damage, along with possible mechanisms, and discusses the possibility of targeting TRPV4 for therapy.
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Citations
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Trpv protein family—from mechanosensing to cancer invasion
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- 13 Jul 2021
TL;DR: In this paper, the authors focus on the vanilloid family of TRP proteins and their connection to cancer progression through their mechanosensitive nature and show that they are critical components in the rapid transmission of physical signals into biologically compatible information to impact crucial processes during development and morphogenesis.
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Mechanosensitive Ion Channels and Their Role in Cancer Cells
TL;DR: A review of the latest literature on the role of the Piezo1 and TRP families in the molecular mechanisms of carcinogenesis in different types of cancer is presented in this paper .
Transient receptor potential cation channel subfamily V (TRPV) and its importance in asthma.
TL;DR: In this article , the authors summarized the contribution of transient receptor potential (TRP) ion channels to the pathogenesis of asthma and proposed a novel biomarker for asthma in children, which may serve as novel therapeutic targets for this ailment.
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Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress.
Naima Eltuhami M. Endesh,Eulashini Chuntharpursat-Bon,Charlotte H. Revill,Nadira Yuldasheva,T. Simon Futers,Gregory Parsonage,Neil E. Humphreys,Antony Adamson,Lara C Morley,Richard M Cubbon,K. Raj Prasad,Richard Foster,Laeticia Lichtenstein,David J. Beech +13 more
TL;DR: In this paper , the authors determined the relevance and relationship of PIEZO1 and TRPV4 channels in the contractile tone of the hepatic portal vein, which experiences mechanical and osmotic variations as it delivers blood to the liver from intestines, gallbladder, pancreas and spleen.
15
References
Free Radicals in the Physiological Control of Cell Function
TL;DR: There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression.
The transient receptor potential family of ion channels
Bernd Nilius,Grzegorz Owsianik +1 more
TL;DR: Mutations in several TRP genes have been implicated in diverse pathological states, including neurodegenerative disorders, skeletal dysplasia, kidney disorders and pain, and ongoing research may help find new therapies for treatments of related diseases.
Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function
Swapnil K. Sonkusare,Adrian D. Bonev,Jonathan Ledoux,Jonathan Ledoux,Wolfgang Liedtke,Michael I. Kotlikoff,Thomas J. Heppner,David C. Hill-Eubanks,Mark T. Nelson,Mark T. Nelson +9 more
TL;DR: Results support the concept that Ca2+ influx through single TRPV4 channels is leveraged by the amplifier effect of cooperative channel gating and the high Ca2- sensitivity of IK and SK channels to cause vasodilation.
505
TRPV4 Forms a Novel Ca2+ Signaling Complex With Ryanodine Receptors and BKCa Channels
TL;DR: It is concluded that TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels that elicits smooth muscle hyperpolarization and arterial dilation via Ca2-induced Ca1+ release in response to an endothelial-derived factor.
465
Transient Receptor Potential Channels in the Vasculature
Scott Earley,Joseph E. Brayden +1 more
TL;DR: The mammalian genome encodes 28 distinct members of the transient receptor potential (TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for different ionic species, including sensory perception and signal transduction.
383