Book Chapter10.1007/978-3-642-97234-8_16
Rhino Mouse Model
Gerd Plewig,Albert M. Kligman +1 more
- 01 Jan 1993
- pp 241-243
TL;DR: Rhinocerous mice which have excessively wrinkled skin were first described in 1856 by Gaskoyne, although a detailed description of these peculiar changes was not given until a century later by Mann.
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Abstract: Rhinocerous mice which have excessively wrinkled skin were first described in 1856 by Gaskoyne, although a detailed description of these peculiar changes was not given until a century later by Mann.
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References
The effect on rhino mouse skin of agents which influence keratinization and exfoliation.
TL;DR: The skin of the rhino mouse, an allelic variant of the hariless mouse, contains deep dermal cysts and huge numbers of hornfilled utriculi which resemble comedones, a suitable model for assessing chemicals which affect epithelial differentiation (retinoids) or which promote loss of cohesion between horny cells (descaling agents).
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Histologic Changes in the Skin of the Rhino Mouse (hrrhhrrh) Induced by Retinoids
TL;DR: A dose-dependent hyperplasia and thickening of the epidermis and the stratum granulosum was induced by the retinoids when given at subtoxic doses, being most marked after arotinoid or RA.
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Topical and systemic effects of retinoids on horn-filled utriculus size in the rhino mouse. A model to quantify "antikeratinizing" effects of retinoids.
TL;DR: The rhino mouse model represents a novel and useful assay to quantify antikeratinizing activity and potency differences of biologically active retinoids.
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The rhino mouse model: the effects of topically applied all-trans retinoic acid and CD271 on the fine structure of the epidermis and utricle wall of pseudocomedones
TL;DR: It is demonstrated that topically applied CD271 induces modifications similar to those obtained with all-trans retinoic acid, and it is concluded that CD271 is a potentially effective anti-acne agent.
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