Resveratrol increases antioxidant defenses and decreases proinflammatory cytokines in hippocampal astrocyte cultures from newborn, adult and aged Wistar rats.

TL;DR: The most recent findings on mechanisms of action involved in the protective effects of this multi target polyphenol are summarized, and its possible roles in the prevention of various age-related neurological disorders are discussed.

TL;DR: Current understanding and information on the role of resveratrol in cellular defense system against oxidative stress are provided.

TL;DR: Natural products from plants represent interesting candidates for AD treatment and may qualify as promising compounds for the development of derivatives providing enhanced pharmacological features.

TL;DR: Resveratrol-loaded solid lipid nanoparticles functionalized with apolipoprotein E which can be recognized by the LDL receptors overexpressed on the blood–brain barrier were functionalized to protect it from degradation in the blood stream.

TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.

TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.

TL;DR: A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.

TL;DR: After a long lag period, therapeutic and other interventions based on a knowledge of redox biology are on the horizon for at least some of the neurodegenerative diseases.