Resveratrol and Omega-3 Fatty Acid: Its Implications in Cardiovascular Diseases
Bibhuti Bhusan Kakoti,Diana G. Hernandez-Ontiveros,Manjir Sarma Kataki,Kajri Shah,Yashwant Pathak,Siva K. Panguluri +5 more
TL;DR: The potential cardioprotective role of resveratrol and O3FAs in ameliorating the endoplasmic reticulum stress is described.
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Abstract: The present review aims at summarizing the major therapeutic roles of resveratrol and omega-3 fatty acids (O3FAs) along with their related pathways. This article reviews some of the key studies involving the health benefits of resveratrol and O3FAs. Oxidative stress has been considered as one of the most important pathophysiological factors associated with various cardiovascular disease conditions. Resveratrol, with the potent antioxidant and free radical scavenging properties, has been proven to be a significantly protective compound in restoring the normal cardiac health. A plethora of research also demonstrated the reduction of the risk of coronary heart disease, hypertension, and stroke, and their complications by O3FAs derived from fish and fish oils. This review describes the potential cardioprotective role of resveratrol and O3FAs in ameliorating the endoplasmic reticulum stress.
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Citations
The Anti-Inflammatory and Antioxidant Properties of n-3 PUFAs: Their Role in Cardiovascular Protection.
Francesca Oppedisano,Roberta Macrì,Micaela Gliozzi,Vincenzo Musolino,Cristina Carresi,Jessica Maiuolo,Francesca Bosco,Saverio Nucera,Maria Caterina Zito,Lorenza Guarnieri,Federica Scarano,Caterina Nicita,Anna Rita Coppoletta,Stefano Ruga,Miriam Scicchitano,Rocco Mollace,Ernesto Palma,Vincenzo Mollace +17 more
TL;DR: The molecular mechanisms underlying the anti-oxidant and anti-inflammatory effect of n-3 PUFAs in vascular and cardiac tissues and their implication in the prevention and treatment of cardiovascular disease are summarized.
198
Shared metabolic and immune-inflammatory, oxidative and nitrosative stress pathways in the metabolic syndrome and mood disorders
Luiz Gustavo Piccoli de Melo,Sandra Odebrecht Vargas Nunes,George M. Anderson,Heber Odebrecht Vargas,Décio Sabbattini Barbosa,Piotr Gałecki,André F. Carvalho,Michael Maes +7 more
TL;DR: Given the high levels of IO&NS and metabolic dysregulation in BD and MDD and the high comorbidity with the atherogenic components of the MetS, mood disorders should be viewed as systemic neuro‐IO&NS‐metabolic disorders.
171
Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults - A randomized controlled trial.
Sebastian Huhn,Sebastian Huhn,Frauke Beyer,Frauke Beyer,Rui Zhang,Rui Zhang,Leonie Lampe,Jana Grothe,Jürgen Kratzsch,Anja Willenberg,Jana Breitfeld,Peter Kovacs,Michael Stumvoll,Robert Trampel,Pierre-Louis Bazin,Pierre-Louis Bazin,Pierre-Louis Bazin,Arno Villringer,Arno Villringer,A. Veronica Witte,A. Veronica Witte +20 more
TL;DR: 6 months resveratrol supplementation showed no significant effects on verbal memory compared to placebo, and the findings indicate the feasibility to detect (un)healthy aging‐related changes in measures of hippocampus microstructure after 6 months using 7T diffusion MRI.
83
The Natural Occurring Compounds Targeting Endoplasmic Reticulum Stress
TL;DR: The natural occurring compounds targeting ER stress, which results in medical benefits to human diseases, mainly include polyphenols, alkaloids, and saponins are summarized.
Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects
Thiago de Melo Costa Pereira,Fábio da Silva Pimenta,Marcella L. Porto,Marcelo Perim Baldo,Bianca Prandi Campagnaro,Agata L. Gava,Silvana S. Meyrelles,Elisardo Corral Vasquez,Elisardo Corral Vasquez +8 more
TL;DR: New promising therapeutic coadjuvants are highlighted, including chemical scavengers, the probiotic kefir and the phosphodiesterase 5 inhibitors, which besides the reduction of hyperglycemia and ameliorate insulin resistance, they reduce oxidative stress and improve endothelial dysfunction in the systemic vascular circulation.
49
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