Reference Entry10.1002/047120918X.EMB1314
Restriction–Modification Systems
S. S. Szegedi,R. I. Gumport +1 more
- 15 Jan 2002
20
About: The article was published on 15 Jan 2002.
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Citations
Bacterial Genome Instability
Elise Darmon,David R. F. Leach +1 more
TL;DR: The specialized genetic elements and the endogenous processes that contribute to genome instability are described and the consequences of genome instability at the physiological level, and at the evolutionary level, where horizontal gene transfer has played an important role.
398
The interplay of restriction-modification systems with mobile genetic elements and their prokaryotic hosts
TL;DR: This work analyzed the distribution of R-M systems in 2261 prokaryote genomes and found their frequency to be strongly dependent on the presence of MGEs, CRISPR-Cas systems, integrons and natural transformation.
304
Defining the plasmid-borne restriction-modification systems of the Lyme disease spirochete Borrelia burgdorferi.
TL;DR: Results indicate that the bbe02 and bbq67 loci of B. burgdorferi encode distinct R-M enzymes that methylate endogenous DNA and cleave foreign DNA lacking the same sequence-specific modification.
97
Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes
Chao Chen,Chao Chen,Lianrong Wang,Si Chen,Xiaolin Wu,Xiaolin Wu,Meijia Gu,Xi Chen,Susu Jiang,Yunfu Wang,Zixin Deng,Peter C. Dedon,Shi Chen +12 more
TL;DR: The discovery of shared consensus sequences for two seemingly unrelated DNA modification systems, 6mA methylation and phosphorothioation (PT), in which sulfur replaces a nonbridging oxygen in the DNA backbone is described.
65
Dam and Dcm methylations prevent gene transfer into Clostridium pasteurianum NRRL B-598: development of methods for electrotransformation, conjugation, and sonoporation.
TL;DR: It is shown that the use of unmethylated plasmid DNA is necessary for efficient transformation or successful conjugation of C. pasteurianum NRRL B-598, and both Dam and Dcm methylations are detrimental for transformation.
References
Restriction and Modification Systems
TL;DR: The history and present situation of R-M, as well as other aspects of human evolution, are reviewed in detail.
770
Biology of DNA restriction.
Thomas A. Bickle,D H Krüger +1 more
TL;DR: The discovery of a new class of restriction systems that specifically cut DNA carrying the modification signature of foreign cells, and the mechanisms developed by phages to avoid the restriction systems of their hosts are described.
676
Selfish behavior of restriction-modification systems
TL;DR: Plasmids carrying gene pairs encoding type II DNA restriction endonucleases and their cognate modification enzymes were shown to have increased stability in Escherichia coli, showing the capacity of these genes to act as a selfish symbiont to contribute to the evolution of restriction-modification gene pairs.
388
On the Origins, Structures and Functions of Restriction-Modification Enzymes
TL;DR: Study on anti-restriction systems, the repair of DNA single- and double-strand breaks, and the roles of DNA lesions in recombination initiation, suggest RM systems may provoke genome rearrangements and assimilate foreign DNA into the host genome and point towards possible evolutionary sources of this interesting group of DNA metabolizing enzymes.
95
DNA restriction-modification systems mediate plasmid maintenance.
TL;DR: It is proposed that R-M systems mediate plasmid segregational stability by postsegregational killing of plasmID-free cells by contributing to plasmids stability is a previously unrecognized biological role of the R- M systems.
91
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