Journal Article10.1167/IOVS.04-1174
Reproducibility of retinal nerve fiber thickness measurements using the stratus OCT in normal and glaucomatous eyes.
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TL;DR: Reproducibility of RNFL measurements using the Stratus OCT is excellent in normal and glaucomatous eyes, and Standard RNFL and Fast RNFL scans are equally reproducible and yield comparable measurements.
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Abstract: PURPOSE. To determine the reproducibility of Stratus Optical Coherence Tomography (OCT) retinal nerve fiber layer (RNFL) measurements around the optic nerve in normal and glaucomatous eyes. METHODS. One eye was chosen at random from 88 normal subjects and 59 glaucomatous subjects distributed among mild, moderate, and severe glaucoma, determined by visual field testing. Subjects underwent six RNFL thickness measurements performed by a single operator over a 30-minute period with a brief rest between sessions. Three scans were taken with the high-density Standard RNFL protocol, and three were taken with the Fast RNFL protocol, alternating between scan protocols. RESULTS. Reliability, as measured by intraclass correlation coefficient (ICC), was calculated for the overall mean RNFL thickness and for each quadrant. The ICC for the mean Standard RNFL thickness (and lower 95% confidence interval [CI]) in normal and glaucomatous eyes was 0.97 (0.96 CI) and 0.98 (0.97 CI), respectively. The ICC for the mean Fast RNFL thickness in normal and glaucomatous eyes was 0.95 (0.93 CI) and 0.97 (0.95 CI), respectively. Quadrant ICCs ranged between 0.79 and 0.97, with the nasal quadrant being the least reproducible of all four quadrants, using either the Standard or Fast RNFL program. The test‐retest variability ranged from 3.5 m for the average RNFL thickness measurements in normal eyes to 13.8 m for the nasal quadrant measurements in glaucomatous eyes, which appeared to be the most variable. CONCLUSIONS. Reproducibility of RNFL measurements using the Stratus OCT is excellent in normal and glaucomatous eyes. The nasal quadrant appears to be the most variable measurement. Standard RNFL and Fast RNFL scans are equally reproducible and yield comparable measurements. These findings have im
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Optical coherence tomography: a review of clinical development from bench to bedside
TL;DR: A brief history of OCT development is presented, current clinical applications are reviewed, some clinical translation challenges are discussed, and laboratory developments poised for future clinical application are reviewed.
Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study.
Christopher Kai-Shun Leung,Carol Y. Cheung,Robert N. Weinreb,Quanliang Qiu,Quanliang Qiu,Shu Liu,Haitao Li,Guihua Xu,Guihua Xu,Ning Fan,Ning Fan,Lina Huang,Chi Pui Pang,Dennis S.C. Lam +13 more
TL;DR: Although the diagnostic performance and the strength of the structure-function association were comparable between Cirrus HD-OCT and Stratus OCT RNFL measurements, Cirrus' measurement variability demonstrated lower measurement variability compared withstratus OCT with significant differences at 1, 3, 4, and 8 to 11 o'clock.
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Recent developments in optical coherence tomography for imaging the retina.
TL;DR: An overview of the most recent developments in the field of OCT imaging focussing on applications for the retina shows how promising are the developments in contrast-enhanced molecular optical imaging, for example with the use of scattering tuneable nanoparticles targeted at specific tissue or cell structures.
401
Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis.
Lauren S. Talman,Esther R. Bisker,David J. Sackel,David A. Long,Kristin M. Galetta,John N. Ratchford,Deacon J. Lile,Sheena K. Farrell,Michael J. Loguidice,Gina Remington,Amy Conger,Teresa C. Frohman,Dina A. Jacobs,Clyde E. Markowitz,Gary Cutter,Gui-Shuang Ying,Yang Dai,Maureen G. Maguire,Steven L. Galetta,Elliot M. Frohman,Peter A. Calabresi,Laura J. Balcer +21 more
TL;DR: Cross‐sectional studies of optical coherence tomography show that retinal nerve fiber layer thickness is reduced in multiple sclerosis (MS) and correlates with visual function, and how longitudinal changes in RNFL thickness relate to visual loss is determined.
Optical coherence tomography of the retina and optic nerve - a review
TL;DR: The spectral domain OCT became available, a new technique that allowed major improvements particularly regarding image acquisition speed and image resolution, and future studies will address how these major technological advances will impact the use of the OCT in research and clinical practice.
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Optical coherence tomography
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Optical Coherence Tomography
TL;DR: The optical coherence tomograph is a new, noninvasive technical device that can obtain cross-sectional, high-resolution images-optical coherencetomographs (OCT)-of the retina that permits an accurate evaluation of various macular and chorioretinal pathologies and the early detection of glaucomatous damage.
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