Journal Article10.1016/0168-8278(91)90036-B
Replicating and virion secreting hepatitis B mutant virus unable to produce preS2 protein.
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TL;DR: The data demonstrate that HBV with mutated preS sequences and unable to express preS2 protein can occur as a dominant or exclusive virus population in a highly viremic chronic carrier and show that expression of the preS1 protein is not essential for HBV replication, virion morphogenesis and secretion.
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About: This article is published in Journal of Hepatology. The article was published on 01 Jan 1991. The article focuses on the topics: Hepatitis B virus & Viral replication.
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Citations
Hepatitis B virus morphogenesis.
TL;DR: The hepatitis B virus (HBV) particle consists of an envelope containing three related surface proteins and probably lipid and an icosahedral nucleocapsid of approximately 30 nm diameter enclosing the viral DNA genome and DNA polymerase.
How viral genetic variants and genotypes influence disease and treatment outcome of chronic hepatitis B. Time for an individualised approach
TL;DR: New technologies that may allow more informed decision-making for response guided therapy in the battle against HBV are discussed, including next-generation sequencing to assess drug-resistant or immune escape variants and quasi-species heterogeneity in patients.
160
Hepatitis B surface antigen seroclearance: Immune mechanisms, clinical impact, importance for drug development.
TL;DR: Recent studies on immune factors, their influence on CHB progression, and HBsAg seroconversion are reviewed to provide new insights in the development of immune therapeutic approaches to partially restore the anti-HBV immune response.
132
Genotypes and viral variants in chronic hepatitis B: A review of epidemiology and clinical relevance.
TL;DR: Although not currently part of routine clinical care, evaluation of genotype and viral variants may provide useful adjunctive information in predicting risk about liver related morbidity in patients with CHB.
122
Hepatitis B viral factors and clinical outcomes of chronic hepatitis B.
Chih-Lin Lin,Jia-Horng Kao +1 more
TL;DR: In conclusion, hepatitis B viral factors such as serum HBV DNA level, genotype and mutants have already been clarified to influence disease progression of chronic hepatitis B and further studies are needed to investigate the pathogenic mechanism of each viral factor.
117
References
Large surface proteins of hepatitis B virus containing the pre-s sequence.
TL;DR: Immunological cross-reactions showed that P39/GP42 is partially homologous to P24/GP27 and GP33/GP36, and a model is presented of how the open reading frame for the viral envelope leads to defined amounts of three different proteins.
863
Morphogenetic and regulatory effects of mutations in the envelope proteins of an avian hepadnavirus.
TL;DR: The envelope gene of the avian hepadnavirus, duck hepatitis B virus, was mutated in order to dissect the functions of the two major envelope proteins pre-S/S and S, found to be required for virus particle assembly and secretion.
204
Assembly of Hepadnaviral Virions and Subviral Particles
TL;DR: What is known about hepadnaviral structure and assembly is reviewed, with emphasis on recent mutational approaches that examine the role of individual viral gene products in the assembly process for HBV.
169
Emergence of and takeover by hepatitis B virus (HBV) with rearrangements in the pre-S/S and pre-C/C genes during chronic HBV infection.
A Tran,Dina Kremsdorf,Francis Capel,Chantal Housset,C Dauguet,Marie-Anne Petit,Christian Bréchot +6 more
TL;DR: Analysis of serial serum samples from a chronic hepatitis B virus (HBV) carrier shows the emergence of HBV DNA molecules with nucleotide rearrangements in the pre-S/S and pre-C/C genes, which might lead to changes in the immunogenicity of the viral particles and thus affect the clearance of the virus by the immune system.
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